6S73

Crystal structure of Nek7 SRS mutant bound to compound 51

Replaces:  6GT1

Summary for 6S73

• Entry DOI: 10.2210/pdb6s73/pdb
• Related: 6S73 6S76
• Descriptor: Serine/threonine-protein kinase Nek7, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide (2 entities in total)
• Functional Keywords: kinase, mutant, inhibitor, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 144315.32

Authors

Nasir, N.,Byrne, M.J.,Bhatia, C.,Bayliss, R. (deposition date: 2019-07-04, release date: 2020-06-10, Last modification date: 2024-01-24)

• Primary citation: Byrne, M.J.,Nasir, N.,Basmadjian, C.,Bhatia, C.,Cunnison, R.F.,Carr, K.H.,Mas-Droux, C.,Yeoh, S.,Cano, C.,Bayliss, R.; Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.; Biochem.J., 477:1525-1539, 2020; PubMed: 32242624; DOI: 10.1042/BCJ20200128

Experimental method

X-RAY DIFFRACTION (3.5 Å)