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6S73

Crystal structure of Nek7 SRS mutant bound to compound 51

Replaces:  6GT1
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Serine/threonine-protein kinase Nek7polymer31035713.14UniProt (Q8TDX7)
Pfam (PF00069)
Homo sapiens (Human)Never in mitosis A-related kinase 7,NimA-related protein kinase 7
2E, F, G
(A, B, C)
3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamidenon-polymer487.63Chemie (F9N)
Sequence modifications
A, B, C, D: 1 - 302 (UniProt: Q8TDX7)
PDBExternal DatabaseDetails
His 86Leu 86engineered mutation
Phe 97Tyr 97engineered mutation
Phe 180Leu 180engineered mutation
Leu 303-expression tag
Glu 304-expression tag
His 305-expression tag
His 306-expression tag
His 307-expression tag
His 308-expression tag
His 309-expression tag
His 310-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight142852.5
Non-Polymers*Number of molecules3
Total formula weight1462.9
All*Total formula weight144315.3
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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