6S73

Crystal structure of Nek7 SRS mutant bound to compound 51

Replaces:  6GT1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Serine/threonine-protein kinase Nek7	polymer	310	35713.1	4	UniProt (Q8TDX7) Pfam (PF00069) In PDB	Homo sapiens (Human)	Never in mitosis A-related kinase 7,NimA-related protein kinase 7
2	A, B, C	3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide	non-polymer		487.6	3	Chemie (F9N)

Sequence modifications

A, B, C, D: 1 - 302 (UniProt: Q8TDX7)

PDB	External Database	Details
His 86	Leu 86	engineered mutation
Phe 97	Tyr 97	engineered mutation
Phe 180	Leu 180	engineered mutation
Leu 303	-	expression tag
Glu 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	142852.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1462.9
All*	Total formula weight	144315.3

*Water molecules are not included.