Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6S73

Crystal structure of Nek7 SRS mutant bound to compound 51

Replaces: 6GT1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000922	cellular_component	spindle pole
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005815	cellular_component	microtubule organizing center
A	0005874	cellular_component	microtubule
A	0006468	biological_process	protein phosphorylation
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032206	biological_process	positive regulation of telomere maintenance
A	0033044	biological_process	regulation of chromosome organization
A	0035865	biological_process	cellular response to potassium ion
A	0043549	biological_process	regulation of kinase activity
A	0046872	molecular_function	metal ion binding
A	0051225	biological_process	spindle assembly
A	0106310	molecular_function	protein serine kinase activity
A	0140677	molecular_function	molecular function activator activity
A	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
B	0000166	molecular_function	nucleotide binding
B	0000922	cellular_component	spindle pole
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005815	cellular_component	microtubule organizing center
B	0005874	cellular_component	microtubule
B	0006468	biological_process	protein phosphorylation
B	0007346	biological_process	regulation of mitotic cell cycle
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0032206	biological_process	positive regulation of telomere maintenance
B	0033044	biological_process	regulation of chromosome organization
B	0035865	biological_process	cellular response to potassium ion
B	0043549	biological_process	regulation of kinase activity
B	0046872	molecular_function	metal ion binding
B	0051225	biological_process	spindle assembly
B	0106310	molecular_function	protein serine kinase activity
B	0140677	molecular_function	molecular function activator activity
B	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
C	0000166	molecular_function	nucleotide binding
C	0000922	cellular_component	spindle pole
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005815	cellular_component	microtubule organizing center
C	0005874	cellular_component	microtubule
C	0006468	biological_process	protein phosphorylation
C	0007346	biological_process	regulation of mitotic cell cycle
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0032206	biological_process	positive regulation of telomere maintenance
C	0033044	biological_process	regulation of chromosome organization
C	0035865	biological_process	cellular response to potassium ion
C	0043549	biological_process	regulation of kinase activity
C	0046872	molecular_function	metal ion binding
C	0051225	biological_process	spindle assembly
C	0106310	molecular_function	protein serine kinase activity
C	0140677	molecular_function	molecular function activator activity
C	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
D	0000166	molecular_function	nucleotide binding
D	0000922	cellular_component	spindle pole
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005815	cellular_component	microtubule organizing center
D	0005874	cellular_component	microtubule
D	0006468	biological_process	protein phosphorylation
D	0007346	biological_process	regulation of mitotic cell cycle
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0032206	biological_process	positive regulation of telomere maintenance
D	0033044	biological_process	regulation of chromosome organization
D	0035865	biological_process	cellular response to potassium ion
D	0043549	biological_process	regulation of kinase activity
D	0046872	molecular_function	metal ion binding
D	0051225	biological_process	spindle assembly
D	0106310	molecular_function	protein serine kinase activity
D	0140677	molecular_function	molecular function activator activity
D	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue F9N A 401

Chain	Residue
A	ILE40
A	ARG50
A	GLU112
A	ALA114
A	ASP115
A	GLY117
A	ALA165
A	PHE168

site_id	AC2
Number of Residues	8
Details	binding site for residue F9N B 401

Chain	Residue
B	ARG50
B	GLU112
B	ALA114
B	GLY117
B	ARG121
B	ALA165
B	PHE168
B	ILE40

site_id	AC3
Number of Residues	7
Details	binding site for residue F9N C 401

Chain	Residue
C	ARG50
C	GLU112
C	LEU113
C	ALA114
C	ASP115
C	ASP118
C	PHE168

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGQFSEVYrAaclldgvp..........VALK

Chain	Residue	Details
A	ILE40-LYS63

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VmHrDIKpaNVFI

Chain	Residue	Details
A	VAL157-ILE169

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2WQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Autoinhibitory","evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	13
Details	Region: {"description":"NTE motif","evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)