6GN7

X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA aptamer, in the presence of sodium ions.

Summary for 6GN7
Related6EVV
Related PRD IDPRD_000020
DescriptorProthrombin, NU172, DNA (26-MER), N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywordsthrombin-dna, g-quadruplex, aptamer, duplex/quadruplex, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight44046.31
Authors
Troisi, R.,Russo Krauss, I.,Sica, F. (deposition date: 2018-05-30, release date: 2018-10-17, Last modification date: 2020-07-29)
Primary citationNapolitano, V.,Russo Krauss, I.,Sica, F.,Spiridonova, V.,Troisi, R.
Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer.
Nucleic Acids Res., 46:12177-12185, 2018
PubMed: 30357392
DOI: 110.1093/nar/gky990
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation
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PDB entries from 2021-06-16