6EVV
X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA aptamer, in the presence of potassium ions.
Summary for 6EVV
Entry DOI | 10.2210/pdb6evv/pdb |
Related PRD ID | PRD_000020 |
Descriptor | Prothrombin, NU172, DNA (26-MER), N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | thrombin-dna, g-quadruplex, aptamer, duplex/quadruplex, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 44224.55 |
Authors | Troisi, R.,Russo Krauss, I.,Sica, F. (deposition date: 2017-11-02, release date: 2018-10-24, Last modification date: 2024-01-17) |
Primary citation | Troisi, R.,Napolitano, V.,Spiridonova, V.,Russo Krauss, I.,Sica, F. Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer. Nucleic Acids Res., 46:12177-12185, 2018 Cited by PubMed: 30357392DOI: 10.1093/nar/gky990 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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