6EVV

X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA aptamer, in the presence of potassium ions.

Summary for 6EVV

• Entry DOI: 10.2210/pdb6evv/pdb
• Related PRD ID: PRD_000020
• Descriptor: Prothrombin, NU172, DNA (26-MER), N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: thrombin-dna, g-quadruplex, aptamer, duplex/quadruplex, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 44224.55

Authors

Troisi, R.,Russo Krauss, I.,Sica, F. (deposition date: 2017-11-02, release date: 2018-10-24, Last modification date: 2024-01-17)

• Primary citation: Troisi, R.,Napolitano, V.,Spiridonova, V.,Russo Krauss, I.,Sica, F.; Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer.; Nucleic Acids Res., 46:12177-12185, 2018; PubMed: 30357392; DOI: 10.1093/nar/gky990

Experimental method

X-RAY DIFFRACTION (2.5 Å)