6EVV
X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA aptamer, in the presence of potassium ions.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Prothrombin | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | Coagulation factor II |
| 2 | B (H) | Prothrombin | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 3 | C (E) | NU172, DNA (26-MER) | polymer | 26 | 8172.2 | 1 | synthetic construct | ||
| 4 | D (A) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1567.4 | 1 | In PDB GlyTouCan (G88421PE) | |||
| 5 | E (H) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 6 | F (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | G (E) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 8 | H (E) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | I, J, K (L, H, E) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
L: 1 - 14 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asp 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Arg 17 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 42049.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1567.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 608.2 | |
| All* | Total formula weight | 44224.6 |
