6G2N

Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU

Summary for 6G2N

Entry DOI	10.2210/pdb6g2n/pdb
Related	6G22 6G2L 6G2M
Descriptor	5'(3')-deoxyribonucleotidase, cytosolic type, MAGNESIUM ION, [(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic acid, ... (4 entities in total)
Functional Keywords	5'-nucleotidase, dephosphorylation, phosphorylation, had-like, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	48821.80
Authors	Pachl, P.,Rezacova, P.,Brynda, J. (deposition date: 2018-03-23, release date: 2018-07-11, Last modification date: 2024-01-17)
Primary citation	Pachl, P.,Simak, O.,Budesinsky, M.,Brynda, J.,Rosenberg, I.,Rezacova, P. Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases Eur.J.Org.Chem., 2018 Cited by DOI: 10.1002/ejoc.201800515 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation