6G2N
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002953 | molecular_function | 5'-deoxynucleotidase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006204 | biological_process | IMP catabolic process |
| A | 0006249 | biological_process | dCMP catabolic process |
| A | 0008252 | molecular_function | nucleotidase activity |
| A | 0008253 | molecular_function | 5'-nucleotidase activity |
| A | 0008254 | molecular_function | 3'-nucleotidase activity |
| A | 0009223 | biological_process | pyrimidine deoxyribonucleotide catabolic process |
| A | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0019103 | molecular_function | pyrimidine nucleotide binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046038 | biological_process | GMP catabolic process |
| A | 0046045 | biological_process | TMP catabolic process |
| A | 0046050 | biological_process | UMP catabolic process |
| A | 0046055 | biological_process | dGMP catabolic process |
| A | 0046059 | biological_process | dAMP catabolic process |
| A | 0046074 | biological_process | dTMP catabolic process |
| A | 0046079 | biological_process | dUMP catabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0002953 | molecular_function | 5'-deoxynucleotidase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006204 | biological_process | IMP catabolic process |
| B | 0006249 | biological_process | dCMP catabolic process |
| B | 0008252 | molecular_function | nucleotidase activity |
| B | 0008253 | molecular_function | 5'-nucleotidase activity |
| B | 0008254 | molecular_function | 3'-nucleotidase activity |
| B | 0009223 | biological_process | pyrimidine deoxyribonucleotide catabolic process |
| B | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0019103 | molecular_function | pyrimidine nucleotide binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046038 | biological_process | GMP catabolic process |
| B | 0046045 | biological_process | TMP catabolic process |
| B | 0046050 | biological_process | UMP catabolic process |
| B | 0046055 | biological_process | dGMP catabolic process |
| B | 0046059 | biological_process | dAMP catabolic process |
| B | 0046074 | biological_process | dTMP catabolic process |
| B | 0046079 | biological_process | dUMP catabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ASP14 |
| A | ASP16 |
| A | ASP149 |
| A | O84302 |
| A | HOH408 |
| A | HOH409 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue O84 A 302 |
| Chain | Residue |
| A | PHE48 |
| A | ALA50 |
| A | TYR69 |
| A | SER104 |
| A | LEU106 |
| A | LEU107 |
| A | ARG136 |
| A | LYS138 |
| A | MG301 |
| A | HOH402 |
| A | HOH404 |
| A | HOH406 |
| A | HOH408 |
| A | HOH409 |
| A | HOH411 |
| A | HOH419 |
| A | HOH430 |
| A | HOH442 |
| A | HOH459 |
| A | HOH490 |
| A | HOH512 |
| A | ASP14 |
| A | ASP16 |
| A | PHE22 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 301 |
| Chain | Residue |
| B | ASP14 |
| B | ASP16 |
| B | ASP149 |
| B | O84302 |
| B | HOH420 |
| B | HOH421 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue O84 B 302 |
| Chain | Residue |
| B | ASP14 |
| B | ASP16 |
| B | PHE22 |
| B | PHE48 |
| B | LEU49 |
| B | ALA50 |
| B | TYR69 |
| B | SER104 |
| B | PRO105 |
| B | LEU106 |
| B | LEU107 |
| B | ARG136 |
| B | LYS138 |
| B | MG301 |
| B | HOH403 |
| B | HOH409 |
| B | HOH411 |
| B | HOH420 |
| B | HOH421 |
| B | HOH458 |
| B | HOH465 |
| B | HOH480 |
| B | HOH492 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
