6FMI

pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-oxopropan-2-yl)acetamide (ligand 2)

Summary for 6FMI

Entry DOI	10.2210/pdb6fmi/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	protein complex, ubiquitin ligase, hypoxia inducible factor, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	82231.22
Authors	Soares, P.,Lucas, X.,Ciulli, A. (deposition date: 2018-01-31, release date: 2018-04-11, Last modification date: 2018-06-20)
Primary citation	Soares, P.,Lucas, X.,Ciulli, A. Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26:2992-2995, 2018 Cited by PubMed: 29650462 DOI: 10.1016/j.bmc.2018.03.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation