6FMI

pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-oxopropan-2-yl)acetamide (ligand 2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Elongin-B	polymer	104	11956.4	2	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E (B, E)	Elongin-C	polymer	97	10974.6	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F (C, F)	von Hippel-Lindau disease tumor suppressor	polymer	153	17738.0	2	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (Human)	Protein G7,pVHL
4	G, H (C, F)	~{N}-[(2~{S})-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamothioyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]ethanamide	non-polymer		446.6	2	Chemie (DV2)
5	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	125	Chemie (HOH)

Sequence modifications

B, E: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

C, F: 54 - 204 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	81338.0
Non-Polymers*	Number of molecules	2
	Total formula weight	893.2
All*	Total formula weight	82231.2

*Water molecules are not included.