6FMI
pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-oxopropan-2-yl)acetamide (ligand 2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| A | 0030891 | cellular_component | VCB complex |
| A | 0070449 | cellular_component | elongin complex |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| D | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| D | 0030891 | cellular_component | VCB complex |
| D | 0070449 | cellular_component | elongin complex |
| E | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue DV2 C 301 |
| Chain | Residue |
| C | TRP88 |
| C | TYR98 |
| C | PRO99 |
| C | ILE109 |
| C | HIS110 |
| C | SER111 |
| C | TYR112 |
| C | HIS115 |
| C | TRP117 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue DV2 F 301 |
| Chain | Residue |
| C | ARG182 |
| F | TRP88 |
| F | TYR98 |
| F | PRO99 |
| F | ARG107 |
| F | ILE109 |
| F | HIS110 |
| F | SER111 |
| F | TYR112 |
| F | HIS115 |
| F | TRP117 |
| F | HOH414 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 110 |
| Details | Region: {"description":"Involved in binding to CCT complex"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | Region: {"description":"Interaction with Elongin BC complex"} |
| Chain | Residue | Details |
