6FEB

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1086

Summary for 6FEB

• Entry DOI: 10.2210/pdb6feb/pdb
• Related: 6FDI 6FDS 6FDW 6FDX 6FE3 6FE7
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1,2-ETHANEDIOL, (4aS,8aR)-2-[1-(2-aminoquinazolin-4-yl)piperidin-4-yl]-4-(3,4-dimethoxyphenyl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one, ... (7 entities in total)
• Functional Keywords: phosphodiesterase, hydrolase, camp hydrolysis, alternative splicing
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 86989.62

Authors

Singh, A.K.,Brown, D.G. (deposition date: 2017-12-31, release date: 2019-04-10, Last modification date: 2024-01-17)

• Primary citation: Salado, I.G.,Moreno, C.,Sakaine, G.,Singh, A.K.,Blaazer, A.R.,Siderius, M.,Matheeussen, A.,Gul, S.,Maes, L.,Leurs, R.,Brown, D.G.,Augustyns, K.; hPDE4D2 structure with inhibitor NPD-1086; To be published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)