Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | LYS262 |
| A | ASP266 |
| B | HOH611 |
| B | HOH614 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | SER208 |
| A | SER355 |
| A | PRO356 |
| A | CYS358 |
| A | HOH655 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | GLU182 |
| B | LYS255 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | LEU175 |
| A | THR178 |
| A | TRP384 |
| A | ASP391 |
| A | ILE395 |
| A | HOH613 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ASP391 |
| B | THR134 |
| B | ASN251 |
| B | GLN256 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | ASP247 |
| A | PHE249 |
| A | GLN250 |
| A | ARG257 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | GLN210 |
| A | HOH625 |
| A | HOH631 |
| A | HOH653 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | ASP266 |
| A | LEU269 |
| A | LYS275 |
| A | GLN311 |
| A | HOH612 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | ASN278 |
| A | ASP282 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 510 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue D5Z A 511 |
| Chain | Residue |
| A | MET273 |
| A | ASN321 |
| A | ILE336 |
| A | MET337 |
| A | PRO356 |
| A | MET357 |
| A | GLN369 |
| A | PHE372 |
| A | ILE376 |
| A | HOH683 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue D5Z A 512 |
| Chain | Residue |
| A | GLN127 |
| A | LEU132 |
| A | LYS133 |
| A | LYS136 |
| A | ILE137 |
| A | GLU288 |
| A | THR289 |
| A | VAL292 |
| A | THR293 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 513 |
| Chain | Residue |
| A | ASP201 |
| A | HOH621 |
| A | HOH622 |
| A | HOH648 |
| A | HOH665 |
| A | HOH728 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 514 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH621 |
| A | HOH693 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue EPE A 515 |
| Chain | Residue |
| A | HIS105 |
| A | VAL106 |
| A | PHE107 |
| A | ARG108 |
| A | GLU111 |
| A | LEU328 |
| A | GLN331 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | ASN231 |
| A | HOH688 |
| A | HOH714 |
| B | ASN231 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| A | HOH614 |
| A | HOH636 |
| B | LYS262 |
| B | ASP266 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | SER208 |
| B | SER355 |
| B | PRO356 |
| B | CYS358 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| A | PRO179 |
| A | ALA180 |
| A | GLU182 |
| B | THR253 |
| B | LYS254 |
| B | LYS255 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | HIS152 |
| B | THR215 |
| B | SER217 |
| B | GLU243 |
| B | ARG350 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ASP203 |
| B | PRO205 |
| B | LEU219 |
| B | HIS154 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | ASN115 |
| B | GLU150 |
| B | TYR153 |
| B | ASN162 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | LEU175 |
| B | THR178 |
| B | TRP384 |
| B | VAL388 |
| B | ASP391 |
| B | ILE395 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue D5Z B 508 |
| Chain | Residue |
| B | MET273 |
| B | LEU319 |
| B | ASN321 |
| B | ILE336 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| B | ILE376 |
| B | HOH667 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 509 |
| Chain | Residue |
| B | ASP201 |
| B | HOH603 |
| B | HOH628 |
| B | HOH632 |
| B | HOH664 |
| B | HOH687 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 510 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | HOH603 |
| B | HOH672 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue EPE B 511 |
| Chain | Residue |
| B | HIS105 |
| B | VAL106 |
| B | PHE107 |
| B | ARG108 |
| B | GLU111 |
| B | LEU328 |
| B | GLN331 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| B | PHE238 |
| B | ARG257 |
| B | HOH636 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| Chain | Residue | Details |
| A | HIS160 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 | |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
| Chain | Residue | Details |
| A | LYS85 | |
| B | LYS85 | |
