6FEB
Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1086
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 364 | 41808.2 | 2 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | C, D, DA, E, F... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 19 | Chemie (EDO) | |||
| 3 | M, N, Z (A, B) | (4aS,8aR)-2-[1-(2-aminoquinazolin-4-yl)piperidin-4-yl]-4-(3,4-dimethoxyphenyl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one | non-polymer | 512.6 | 3 | Chemie (D5Z) | |||
| 4 | AA, O (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | BA, P (B, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | CA, Q (B, A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 7 | EA, FA (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 79 - 438 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| His 77 | - | expression tag |
| Met 78 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83616.5 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 3373.1 | |
| All* | Total formula weight | 86989.6 |
