6FDW

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-356

Summary for 6FDW

• Entry DOI: 10.2210/pdb6fdw/pdb
• Related: 6FDI 6FDS
• Descriptor: Phosphodiesterase, (4aS,8aR)-2-(1-{2-aminothieno[2,3-d]pyrimidin-4-yl}piperidin-4-yl)-4-(3,4- dimethoxyphenyl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one, ZINC ION, ... (7 entities in total)
• Functional Keywords: parasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 2
• Total formula weight: 82614.53

Authors

Singh, A.K.,Brown, D.G. (deposition date: 2017-12-27, release date: 2019-04-10, Last modification date: 2024-01-17)

• Primary citation: Salado, I.G.,Moreno, C.,Sakaine, G.,Singh, A.K.,Blaazer, A.R.,Siderius, M.,Matheeussen, A.,Gul, S.,Maes, L.,Leurs, R.,Brown, D.G.,Augustyns, K.; TbrPDEB1 structure with inhibitor NPD-356; To be published,

Experimental method

X-RAY DIFFRACTION (1.96 Å)