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6FDS

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-226

Summary for 6FDS
Entry DOI10.2210/pdb6fds/pdb
Related6FDI
DescriptorPhosphodiesterase, GUANIDINE, 1-[2-[4-[(4~{a}~{S},8~{a}~{R})-4-(3,4-dimethoxyphenyl)-1-oxidanylidene-4~{a},5,8,8~{a}-tetrahydrophthalazin-2-yl]piperi din-1-yl]-2-oxidanylidene-ethyl]-4,4-dimethyl-piperidine-2,6-dione, ... (7 entities in total)
Functional Keywordsparasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness
Biological sourceTrypanosoma brucei
Total number of polymer chains2
Total formula weight82973.91
Authors
Singh, A.K.,Brown, D.G. (deposition date: 2017-12-26, release date: 2019-04-10, Last modification date: 2024-01-17)
Primary citationSalado, I.G.,Moreno, C.,Sakaine, G.,Singh, A.K.,Blaazer, A.R.,Siderius, M.,Matheeussen, A.,Gul, S.,Maes, L.,Leurs, R.,Brown, D.G.,Augustyns, K.
TbrPDEB1 structure with inhibitor NPD-226
To be published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

PDB entries from 2024-03-27

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