6E3L

Interferon gamma signalling complex with IFNGR1 and IFNGR2

Summary for 6E3L

• Entry DOI: 10.2210/pdb6e3l/pdb
• Related: 6E3K
• Descriptor: Interferon gamma, Interferon gamma receptor 1, Interferon gamma receptor 2, ... (8 entities in total)
• Functional Keywords: cytokine receptor, protein complex, protein engineering, cytokine
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 147235.68

Authors

Jude, K.M.,Mendoza, J.L.,Garcia, K.C. (deposition date: 2018-07-14, release date: 2019-02-27, Last modification date: 2023-10-11)

• Primary citation: Mendoza, J.L.,Escalante, N.K.,Jude, K.M.,Sotolongo Bellon, J.,Su, L.,Horton, T.M.,Tsutsumi, N.,Berardinelli, S.J.,Haltiwanger, R.S.,Piehler, J.,Engleman, E.G.,Garcia, K.C.; Structure of the IFN gamma receptor complex guides design of biased agonists.; Nature, 567:56-60, 2019; PubMed: 30814731; DOI: 10.1038/s41586-019-0988-7

Experimental method

X-RAY DIFFRACTION (3.8 Å)