6E2Q
Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor
Summary for 6E2Q
| Entry DOI | 10.2210/pdb6e2q/pdb |
| Descriptor | Tyrosine-protein kinase JAK2, Erythropoietin receptor (3 entities in total) |
| Functional Keywords | cytokine receptor, erythropoietin, signal transduction, signaling protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 8 |
| Total formula weight | 258977.05 |
| Authors | Ferrao, R.,Lupardus, P.J. (deposition date: 2018-07-11, release date: 2018-08-08, Last modification date: 2023-10-11) |
| Primary citation | Ferrao, R.D.,Wallweber, H.,Lupardus, P.J. Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. Elife, 7:-, 2018 Cited by PubMed: 30044226DOI: 10.7554/eLife.38089 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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