6E2Q

Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tyrosine-protein kinase JAK2	polymer	483	55805.5	4	UniProt (O60674) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990) In PDB	Homo sapiens (Human)	Janus kinase 2, JAK-2
2	M, N, O, P	Erythropoietin receptor	polymer	83	8938.8	4	UniProt (P19235) In PDB	Homo sapiens (Human)	EPOR, EPO-R
3		water	water		18.0	145	Chemie (HOH)

Sequence modifications

A, B, C, D: 36 - 514 (UniProt: O60674)

PDB	External Database	Details
Gly 34	-	expression tag
Ser 35	-	expression tag
Gly 515	-	expression tag
Ser 516	-	expression tag

M, N, O, P: 273 - 338 (UniProt: P19235)

PDB	External Database	Details
Gly 259	-	expression tag
Ser 260	-	expression tag
Gly 261	-	expression tag
Ser 262	-	expression tag
Gly 263	-	expression tag
Ser 264	-	expression tag
Gly 265	-	expression tag
Ser 266	-	expression tag
Gly 267	-	expression tag
Ser 268	-	expression tag
Gly 269	-	expression tag
Ser 270	-	expression tag
Gly 271	-	expression tag
Ser 272	-	expression tag
Gly 339	-	expression tag
Asn 340	-	expression tag
Ser 341	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	258977.1
All*	Total formula weight	258977.1

*Water molecules are not included.