6E2Q
Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase JAK2 | polymer | 483 | 55805.5 | 4 | UniProt (O60674) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990) | Homo sapiens (Human) | Janus kinase 2, JAK-2 |
| 2 | E, F, G, H (M, N, O, P) | Erythropoietin receptor | polymer | 83 | 8938.8 | 4 | UniProt (P19235) | Homo sapiens (Human) | EPOR, EPO-R |
| 3 | I, J, K, L, M... (A, B, C, D, M...) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 36 - 514 (UniProt: O60674)
M, N, O, P: 273 - 338 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | - | expression tag |
| Ser 35 | - | expression tag |
| Gly 515 | - | expression tag |
| Ser 516 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 259 | - | expression tag |
| Ser 260 | - | expression tag |
| Gly 261 | - | expression tag |
| Ser 262 | - | expression tag |
| Gly 263 | - | expression tag |
| Ser 264 | - | expression tag |
| Gly 265 | - | expression tag |
| Ser 266 | - | expression tag |
| Gly 267 | - | expression tag |
| Ser 268 | - | expression tag |
| Gly 269 | - | expression tag |
| Ser 270 | - | expression tag |
| Gly 271 | - | expression tag |
| Ser 272 | - | expression tag |
| Gly 339 | - | expression tag |
| Asn 340 | - | expression tag |
| Ser 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 258977.1 | |
| All* | Total formula weight | 258977.1 |
