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6E2Q

Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005524molecular_functionATP binding
A0005856cellular_componentcytoskeleton
A0006468biological_processprotein phosphorylation
A0016020cellular_componentmembrane
A0035556biological_processintracellular signal transduction
A0042393molecular_functionhistone binding
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005524molecular_functionATP binding
B0005856cellular_componentcytoskeleton
B0006468biological_processprotein phosphorylation
B0016020cellular_componentmembrane
B0035556biological_processintracellular signal transduction
B0042393molecular_functionhistone binding
C0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
C0005524molecular_functionATP binding
C0005856cellular_componentcytoskeleton
C0006468biological_processprotein phosphorylation
C0016020cellular_componentmembrane
C0035556biological_processintracellular signal transduction
C0042393molecular_functionhistone binding
D0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
D0005524molecular_functionATP binding
D0005856cellular_componentcytoskeleton
D0006468biological_processprotein phosphorylation
D0016020cellular_componentmembrane
D0035556biological_processintracellular signal transduction
D0042393molecular_functionhistone binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P14753
ChainResidueDetails
MLYS281
CGLU442
CLYS450
CLYS504
DLEU352
DGLU442
DLYS450
DLYS504
AGLU442
NLYS281
ALYS504
OLYS281
BGLU442
PLYS281
BLYS504
CLEU352

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120
ChainResidueDetails
ATYR119
BTYR119
CTYR119
DTYR119

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q62120
ChainResidueDetails
ATYR372
ATYR373
BTYR372
BTYR373
CTYR372
CTYR373
DTYR372
DTYR373

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PDB entries from 2024-07-10

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