6E2Q
Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0016020 | cellular_component | membrane |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042393 | molecular_function | histone binding |
| B | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0016020 | cellular_component | membrane |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0042393 | molecular_function | histone binding |
| C | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0016020 | cellular_component | membrane |
| C | 0035556 | biological_process | intracellular signal transduction |
| C | 0042393 | molecular_function | histone binding |
| D | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0016020 | cellular_component | membrane |
| D | 0035556 | biological_process | intracellular signal transduction |
| D | 0042393 | molecular_function | histone binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 162 |
| Details | Domain: {"description":"SH2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Site: {"description":"Breakpoint for translocation to form PCM1-JAK2 fusion protein"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Box 1 motif","evidences":[{"source":"UniProtKB","id":"P16310","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P14753","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
