6DPR

Mapping the binding trajectory of a suicide inhibitor in human indoleamine 2,3-dioxygenase 1

6DPR の概要

• エントリーDOI: 10.2210/pdb6dpr/pdb
• 関連するPDBエントリー: 5WMU 5WMV 5WMW 5WMX 5WN8 6DPQ
• 分子名称: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (2R)-N-(4-chlorophenyl)-2-[cis-4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide, ... (5 entities in total)
• 機能のキーワード: indoleamine 2, 3-dioxygenase, heme-containing enzyme, bms-986205, structure-based design, hido1-selective inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97220.40

構造登録者

Pham, K.N.,Yeh, S.R. (登録日: 2018-06-09, 公開日: 2018-11-07, 最終更新日: 2023-11-29)

• 主引用文献: Pham, K.N.,Yeh, S.R.; Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1.; J. Am. Chem. Soc., 140:14538-14541, 2018; PubMed: 30347977; DOI: 10.1021/jacs.8b07994

実験手法

X-RAY DIFFRACTION (3.2 Å)