6DGE
Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with N5-(1-imino-2-chloroethyl)-L-lysine
Summary for 6DGE
| Entry DOI | 10.2210/pdb6dge/pdb |
| Related | 2JAI 2JAJ 3I2E 3I4A 3P8E 3P8P |
| Descriptor | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N~6~-[(1E)-2-chloroethanimidoyl]-L-lysine (3 entities in total) |
| Functional Keywords | enzyme adduct, hydrolase, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 33845.18 |
| Authors | Monzingo, A.F.,Burstein-Teitelbaum, G.,Er, J.A.V.,Tuley, A.,Fast, W. (deposition date: 2018-05-17, release date: 2018-07-25, Last modification date: 2023-10-11) |
| Primary citation | Burstein-Teitelbaum, G.,Er, J.A.V.,Monzingo, A.F.,Tuley, A.,Fast, W. Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor. Biochemistry, 57:4574-4582, 2018 Cited by PubMed: 29983043DOI: 10.1021/acs.biochem.8b00554 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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