3P8E

Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine

Summary for 3P8E

Entry DOI	10.2210/pdb3p8e/pdb
Related	3I2E 3I4A 3P8P
Descriptor	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N~5~-[(1S)-1-aminopentyl]-L-ornithine (3 entities in total)
Functional Keywords	ddah, nitric oxide synthase regulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	67681.60
Authors	Lluis, M.,Wang, Y.,Monzingo, A.F.,Fast, W.,Robertus, J.D. (deposition date: 2010-10-13, release date: 2010-11-10, Last modification date: 2023-09-06)
Primary citation	Lluis, M.,Wang, Y.,Monzingo, A.F.,Fast, W.,Robertus, J.D. Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1. Chemmedchem, 6:81-88, 2011 Cited by PubMed: 20979083 DOI: 10.1002/cmdc.201000392 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4946 Å)

Structure validation