3I4A
Crystal structure of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) in complex with N5-(1-iminopropyl)-L-ornithine
Summary for 3I4A
| Entry DOI | 10.2210/pdb3i4a/pdb |
| Related | 2JAI 2JAJ 3I2E |
| Descriptor | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N5-(1-iminopropyl)-L-ornithine (3 entities in total) |
| Functional Keywords | ddah, hydrolase, nitric oxide synthase regulation, metal-binding |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 67621.46 |
| Authors | Monzingo, A.F.,Wang, Y.,Hu, S.,Schaller, T.H.,Fast, W.,Robertus, J.D. (deposition date: 2009-07-01, release date: 2009-08-25, Last modification date: 2023-09-06) |
| Primary citation | Wang, Y.,Monzingo, A.F.,Hu, S.,Schaller, T.H.,Robertus, J.D.,Fast, W. Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. Biochemistry, 48:8624-8635, 2009 Cited by PubMed: 19663506DOI: 10.1021/bi9007098 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.898 Å) |
Structure validation
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