6DC8

Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope.

Summary for 6DC8

DescriptorIgG light chain, IgG heavy chain, Microtubule-associated protein tau, ... (6 entities in total)
Functional Keywordsmonoclonal antibody, fab, tau, phosphorylation state -specific antibody, immune system
Biological sourceMus musculus (mouse)
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Total number of polymer chains3
Total molecular weight51308.86
Authors
Chukwu, J.E.,Kong, X.-P. (deposition date: 2018-05-04, release date: 2019-03-20, Last modification date: 2019-04-03)
Primary citation
Chukwu, J.E.,Congdon, E.E.,Sigurdsson, E.M.,Kong, X.P.
Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.
MAbs, 11:477-488, 2019
PubMed: 30794086 (PDB entries with the same primary citation)
DOI: 10.1080/19420862.2019.1574530
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.799 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21920 1.5% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6dc8
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Molmil generated image of 6dc8
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Molmil generated image of 6dc8
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