6DC8
Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL L 301 |
| Chain | Residue |
| L | LEU37 |
| L | LYS39 |
| L | GLU45 |
| L | GLU81 |
| L | ASP82 |
| L | HOH403 |
| L | HOH526 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL H 301 |
| Chain | Residue |
| H | ASN98 |
| H | HOH486 |
| L | TYR49 |
| L | PHE55 |
| L | ASP151 |
| P | PO4501 |
| H | ARG96 |
| H | ASP97 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL H 302 |
| Chain | Residue |
| H | PRO119 |
| H | VAL121 |
| H | THR204 |
| H | LYS208 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 P 501 |
| Chain | Residue |
| H | GOL301 |
| L | TYR32 |
| L | LYS50 |
| L | HIS189 |
| L | HOH412 |
| P | SER404 |
| P | HIS407 |
| P | HOH601 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| P | LYS383 | |
| P | LYS385 | |
| P | LYS395 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | LYS385 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | TYR394 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SER396 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| P | SER400 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | THR403 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SER404 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| P | SER400 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | LYS385 |
