6D94

Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1

Summary for 6D94

Entry DOI	10.2210/pdb6d94/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, Mediator of RNA polymerase II transcription subunit 1, (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, super agonist, ligand binding domain, coactivator, med1, dna binding protein, dna binding protein-agonist complex, dna binding protein/agonist
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	37263.03
Authors	Mou, T.C.,Chrisman, I.M.,Hughes, T.S.,Sprang, S.R. (deposition date: 2018-04-27, release date: 2019-05-01, Last modification date: 2023-10-25)
Primary citation	Nemetchek, M.D.,Chrisman, I.M.,Rayl, M.L.,Voss, A.H.,Hughes, T.S. A structural mechanism of nuclear receptor biased agonism. Proc.Natl.Acad.Sci.USA, 119:e2215333119-e2215333119, 2022 Cited by PubMed: 36469765 DOI: 10.1073/pnas.2215333119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation