6D94

Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue EDK A 501

Chain	Residue
A	PHE282
A	PHE360
A	PHE363
A	MET364
A	HIS449
A	TYR473
A	HOH643
A	GLY284
A	CYS285
A	GLN286
A	SER289
A	HIS323
A	LEU330
A	ILE341
A	MET348

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	265
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

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