6D94

Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peroxisome proliferator-activated receptor gamma	polymer	297	34152.4	1	UniProt (P37231) Pfam (PF00104)	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	B (B)	Mediator of RNA polymerase II transcription subunit 1	polymer	24	2615.0	1	UniProt (Q15648)	Homo sapiens	Activator-recruited cofactor 205 kDa component,ARC205,Mediator complex subunit 1,Peroxisome proliferator-activated receptor-binding protein,PPAR-binding protein,Thyroid hormone receptor-associated protein complex 220 kDa component,Trap220,Thyroid receptor-interacting protein 2,TRIP-2,Vitamin D receptor-interacting protein complex component DRIP205,p53 regulatory protein RB18A
3	C (A)	(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid	non-polymer		495.6	1	Chemie (EDK)
4	D, E (A, B)	water	water		18.0	131	Chemie (HOH)

Sequence modifications

A: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 181	-	initiating methionine
Ala 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
Val 189	-	expression tag
Asp 190	-	expression tag
Asp 191	-	expression tag
Asp 192	-	expression tag
Asp 193	-	expression tag
Lys 194	-	expression tag
Met 195	-	expression tag
Glu 196	-	expression tag
Asn 197	-	expression tag
Leu 198	-	expression tag
Tyr 199	-	expression tag
Phe 200	-	expression tag
Gln 201	-	expression tag
Gly 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36767.5
Non-Polymers*	Number of molecules	1
	Total formula weight	495.6
All*	Total formula weight	37263.0

*Water molecules are not included.