6D1U
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin
Summary for 6D1U
| Entry DOI | 10.2210/pdb6d1u/pdb |
| Related | 4rwf 4rwg 5v6y |
| Related PRD ID | PRD_900001 |
| Descriptor | Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, ADM2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (5 entities in total) |
| Functional Keywords | cgrp receptor, class b gpcr, peptide hormone, amidated peptide, peptide binding protein |
| Biological source | Escherichia coli O157:H7 More |
| Total number of polymer chains | 6 |
| Total formula weight | 205807.54 |
| Authors | Pioszak, A.,Roehrkasse, A. (deposition date: 2018-04-12, release date: 2018-09-05, Last modification date: 2023-10-04) |
| Primary citation | Roehrkasse, A.M.,Booe, J.M.,Lee, S.M.,Warner, M.L.,Pioszak, A.A. Structure-function analyses reveal a triple beta-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J. Biol. Chem., 293:15840-15854, 2018 Cited by PubMed: 30139742DOI: 10.1074/jbc.RA118.005062 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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