6D1U
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor | polymer | 593 | 66304.6 | 3 | UniProt (P0AEY0) UniProt (O60894) UniProt (Q16602) Pfam (PF01547) Pfam (PF04901) Pfam (PF02793) UniProt (by SIFTS) (P0AEX9) | Escherichia coli O157:H7 | MBP,MMBP,Maltodextrin-binding protein,Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1,CGRP type 1 receptor,Calcitonin receptor-like receptor |
| 2 | D, E, F (D, E, F) | ADM2 | polymer | 20 | 1925.0 | 3 | UniProt (by SIFTS) (Q7Z4H4) | Homo sapiens | Intermedin |
| 3 | G, H, I (G, H, I) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 3 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 4 | J, K, L, M (A, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | N, O, P, Q, R... (A, B, C, D, E...) | water | water | 18.0 | 530 | Chemie (HOH) |
Sequence modifications
A, B, C: 2 - 368 (UniProt: P0AEY0)
A, B, C: 1024 - 1111 (UniProt: O60894)
A, B, C: 2029 - 2144 (UniProt: Q16602)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Asn 369 | - | linker |
| Ala 370 | - | linker |
| Ala 371 | - | linker |
| Ala 372 | - | linker |
| Glu 373 | - | linker |
| Phe 374 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 2020 | - | linker |
| Ser 2021 | - | linker |
| Ala 2022 | - | linker |
| Gly 2023 | - | linker |
| Ser 2024 | - | linker |
| Ala 2025 | - | linker |
| Gly 2026 | - | linker |
| Ser 2027 | - | linker |
| Ala 2028 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| His 2145 | - | expression tag |
| His 2146 | - | expression tag |
| His 2147 | - | expression tag |
| His 2148 | - | expression tag |
| His 2149 | - | expression tag |
| His 2150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 204688.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1026.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 92.0 | |
| All* | Total formula weight | 205807.5 |
