6C4J

Ligand bound full length hUGDH with A104L substitution

Summary for 6C4J

DescriptorUDP-glucose 6-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE-GLUCOSE, ... (7 entities in total)
Functional Keywordshugdh, human udp-glucose dehydrogenase, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains12
Total molecular weight678074.92
Authors
Beattie, N.R.,Pioso, B.J.,Wood, Z.A.,Sidlo, A.M. (deposition date: 2018-01-12, release date: 2018-05-16, Last modification date: 2018-12-26)
Primary citation
Beattie, N.R.,Pioso, B.J.,Sidlo, A.M.,Keul, N.D.,Wood, Z.A.
Hysteresis and Allostery in Human UDP-Glucose Dehydrogenase Require a Flexible Protein Core.
Biochemistry, 57:6848-6859, 2018
PubMed: 30457329 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.8b00497
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.53 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21430 1.0% 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6c4j
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Molmil generated image of 6c4j
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Molmil generated image of 6c4j
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More Biological unit images

Molmil generated image of 6c4j
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Molmil generated image of 6c4j
rotated about x axis by 90°
Molmil generated image of 6c4j
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6c4j.pdb1.gz [926.95 KB])
Coordinate files for Biological unit (6c4j.pdb2.gz [938.76 KB])
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