Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6C4J

Ligand bound full length hUGDH with A104L substitution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001702	biological_process	gastrulation with mouth forming second
A	0003824	molecular_function	catalytic activity
A	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006024	biological_process	glycosaminoglycan biosynthetic process
A	0006065	biological_process	UDP-glucuronate biosynthetic process
A	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0034214	biological_process	protein hexamerization
A	0042802	molecular_function	identical protein binding
A	0048666	biological_process	neuron development
A	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
B	0001702	biological_process	gastrulation with mouth forming second
B	0003824	molecular_function	catalytic activity
B	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006024	biological_process	glycosaminoglycan biosynthetic process
B	0006065	biological_process	UDP-glucuronate biosynthetic process
B	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0034214	biological_process	protein hexamerization
B	0042802	molecular_function	identical protein binding
B	0048666	biological_process	neuron development
B	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
C	0001702	biological_process	gastrulation with mouth forming second
C	0003824	molecular_function	catalytic activity
C	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006024	biological_process	glycosaminoglycan biosynthetic process
C	0006065	biological_process	UDP-glucuronate biosynthetic process
C	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0034214	biological_process	protein hexamerization
C	0042802	molecular_function	identical protein binding
C	0048666	biological_process	neuron development
C	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
D	0001702	biological_process	gastrulation with mouth forming second
D	0003824	molecular_function	catalytic activity
D	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006024	biological_process	glycosaminoglycan biosynthetic process
D	0006065	biological_process	UDP-glucuronate biosynthetic process
D	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0034214	biological_process	protein hexamerization
D	0042802	molecular_function	identical protein binding
D	0048666	biological_process	neuron development
D	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome
E	0001702	biological_process	gastrulation with mouth forming second
E	0003824	molecular_function	catalytic activity
E	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006024	biological_process	glycosaminoglycan biosynthetic process
E	0006065	biological_process	UDP-glucuronate biosynthetic process
E	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0034214	biological_process	protein hexamerization
E	0042802	molecular_function	identical protein binding
E	0048666	biological_process	neuron development
E	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
E	0051287	molecular_function	NAD binding
E	0070062	cellular_component	extracellular exosome
F	0001702	biological_process	gastrulation with mouth forming second
F	0003824	molecular_function	catalytic activity
F	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005829	cellular_component	cytosol
F	0006024	biological_process	glycosaminoglycan biosynthetic process
F	0006065	biological_process	UDP-glucuronate biosynthetic process
F	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0034214	biological_process	protein hexamerization
F	0042802	molecular_function	identical protein binding
F	0048666	biological_process	neuron development
F	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
F	0051287	molecular_function	NAD binding
F	0070062	cellular_component	extracellular exosome
G	0001702	biological_process	gastrulation with mouth forming second
G	0003824	molecular_function	catalytic activity
G	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006024	biological_process	glycosaminoglycan biosynthetic process
G	0006065	biological_process	UDP-glucuronate biosynthetic process
G	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0034214	biological_process	protein hexamerization
G	0042802	molecular_function	identical protein binding
G	0048666	biological_process	neuron development
G	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
G	0051287	molecular_function	NAD binding
G	0070062	cellular_component	extracellular exosome
H	0001702	biological_process	gastrulation with mouth forming second
H	0003824	molecular_function	catalytic activity
H	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005829	cellular_component	cytosol
H	0006024	biological_process	glycosaminoglycan biosynthetic process
H	0006065	biological_process	UDP-glucuronate biosynthetic process
H	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0034214	biological_process	protein hexamerization
H	0042802	molecular_function	identical protein binding
H	0048666	biological_process	neuron development
H	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
H	0051287	molecular_function	NAD binding
H	0070062	cellular_component	extracellular exosome
I	0001702	biological_process	gastrulation with mouth forming second
I	0003824	molecular_function	catalytic activity
I	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005829	cellular_component	cytosol
I	0006024	biological_process	glycosaminoglycan biosynthetic process
I	0006065	biological_process	UDP-glucuronate biosynthetic process
I	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0034214	biological_process	protein hexamerization
I	0042802	molecular_function	identical protein binding
I	0048666	biological_process	neuron development
I	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
I	0051287	molecular_function	NAD binding
I	0070062	cellular_component	extracellular exosome
J	0001702	biological_process	gastrulation with mouth forming second
J	0003824	molecular_function	catalytic activity
J	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005829	cellular_component	cytosol
J	0006024	biological_process	glycosaminoglycan biosynthetic process
J	0006065	biological_process	UDP-glucuronate biosynthetic process
J	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J	0034214	biological_process	protein hexamerization
J	0042802	molecular_function	identical protein binding
J	0048666	biological_process	neuron development
J	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
J	0051287	molecular_function	NAD binding
J	0070062	cellular_component	extracellular exosome
K	0001702	biological_process	gastrulation with mouth forming second
K	0003824	molecular_function	catalytic activity
K	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005829	cellular_component	cytosol
K	0006024	biological_process	glycosaminoglycan biosynthetic process
K	0006065	biological_process	UDP-glucuronate biosynthetic process
K	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
K	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K	0034214	biological_process	protein hexamerization
K	0042802	molecular_function	identical protein binding
K	0048666	biological_process	neuron development
K	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
K	0051287	molecular_function	NAD binding
K	0070062	cellular_component	extracellular exosome
L	0001702	biological_process	gastrulation with mouth forming second
L	0003824	molecular_function	catalytic activity
L	0003979	molecular_function	UDP-glucose 6-dehydrogenase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005829	cellular_component	cytosol
L	0006024	biological_process	glycosaminoglycan biosynthetic process
L	0006065	biological_process	UDP-glucuronate biosynthetic process
L	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
L	0016491	molecular_function	oxidoreductase activity
L	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L	0034214	biological_process	protein hexamerization
L	0042802	molecular_function	identical protein binding
L	0048666	biological_process	neuron development
L	0050650	biological_process	chondroitin sulfate proteoglycan biosynthetic process
L	0051287	molecular_function	NAD binding
L	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue NAD A 501

Chain	Residue
A	GLY13
A	GLU161
A	CYS276
A	LYS279
A	UPG502
A	TYR14
A	VAL15
A	VAL89
A	ASN90
A	THR91
A	TYR108
A	CYS112
A	THR131

site_id	AC2
Number of Residues	23
Details	binding site for residue UPG A 502

Chain	Residue
A	PHE162
A	LEU163
A	ALA164
A	GLU165
A	LYS220
A	ASN224
A	ILE231
A	PHE265
A	LEU266
A	LYS267
A	SER269
A	PHE272
A	GLY273
A	CYS276
A	PHE277
A	PHE338
A	LYS339
A	ARG442
A	NAD501
A	HOH610
A	HOH614
A	HOH615
B	ARG260

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 503

Chain	Residue
A	ARG135
A	TRP214

site_id	AC4
Number of Residues	19
Details	binding site for residue NAD B 501

Chain	Residue
B	ILE10
B	GLY11
B	GLY13
B	TYR14
B	VAL15
B	ASP36
B	VAL37
B	ARG41
B	ILE75
B	SER88
B	VAL89
B	ASN90
B	THR91
B	TYR108
B	SER130
B	THR131
B	GLU161
B	LYS279
B	UPG502

site_id	AC5
Number of Residues	21
Details	binding site for residue UPG B 502

Chain	Residue
A	ARG260
B	PHE162
B	LEU163
B	ALA164
B	GLU165
B	LYS220
B	ASN224
B	ILE231
B	PHE265
B	LEU266
B	LYS267
B	SER269
B	PHE272
B	GLY273
B	CYS276
B	PHE277
B	PHE338
B	LYS339
B	ARG442
B	NAD501
B	HOH604

site_id	AC6
Number of Residues	1
Details	binding site for residue CL B 503

Chain	Residue
B	GLY99

site_id	AC7
Number of Residues	1
Details	binding site for residue CL B 504

Chain	Residue
B	ARG135

site_id	AC8
Number of Residues	17
Details	binding site for residue NAD C 501

Chain	Residue
C	ILE10
C	GLY11
C	GLY13
C	TYR14
C	VAL15
C	ASP36
C	VAL37
C	ARG41
C	VAL89
C	ASN90
C	THR91
C	TYR108
C	SER130
C	THR131
C	GLU161
C	LYS279
C	UPG502

site_id	AC9
Number of Residues	20
Details	binding site for residue UPG C 502

Chain	Residue
C	GLU165
C	LYS220
C	ASN224
C	ILE231
C	PHE265
C	LEU266
C	LYS267
C	SER269
C	PHE272
C	GLY273
C	CYS276
C	PHE277
C	PHE338
C	LYS339
C	ARG442
C	NAD501
C	HOH616
D	ARG260
C	PHE162
C	LEU163

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 C 503

Chain	Residue
C	ARG135
C	TRP214

site_id	AD2
Number of Residues	18
Details	binding site for residue NAD D 501

Chain	Residue
D	ILE10
D	GLY11
D	GLY13
D	TYR14
D	VAL15
D	ASP36
D	VAL37
D	ARG41
D	SER88
D	VAL89
D	ASN90
D	THR91
D	TYR108
D	SER130
D	THR131
D	GLU161
D	LYS279
D	UPG502

site_id	AD3
Number of Residues	23
Details	binding site for residue UPG D 502

Chain	Residue
C	ARG260
D	PHE162
D	LEU163
D	ALA164
D	GLU165
D	LYS220
D	ASN224
D	ILE231
D	PHE265
D	LEU266
D	LYS267
D	SER269
D	PHE272
D	GLY273
D	CYS276
D	PHE277
D	PHE338
D	LYS339
D	ARG442
D	NAD501
D	HOH606
D	HOH611
D	HOH624

site_id	AD4
Number of Residues	2
Details	binding site for residue CL D 503

Chain	Residue
D	GLY99
D	ARG102

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 D 504

Chain	Residue
D	ASN263
D	LYS264
K	ARG31
K	PHE70

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 D 505

Chain	Residue
C	LYS465
D	ARG135
D	TRP214

site_id	AD7
Number of Residues	5
Details	binding site for residue PGO D 506

Chain	Residue
C	ASP258
C	ARG260
D	ASP171
D	ASP176
D	ARG177

site_id	AD8
Number of Residues	21
Details	binding site for residue NAD E 501

Chain	Residue
E	ILE10
E	GLY11
E	GLY13
E	TYR14
E	VAL15
E	ASP36
E	VAL37
E	ARG41
E	SER88
E	VAL89
E	ASN90
E	THR91
E	TYR108
E	SER130
E	THR131
E	GLU161
E	LYS279
E	UPG502
E	HOH633
E	HOH634
E	HOH639

site_id	AD9
Number of Residues	22
Details	binding site for residue UPG E 502

Chain	Residue
E	PHE162
E	LEU163
E	ALA164
E	GLU165
E	LYS220
E	ASN224
E	ILE231
E	PHE265
E	LEU266
E	LYS267
E	SER269
E	PHE272
E	GLY273
E	CYS276
E	PHE277
E	PHE338
E	LYS339
E	ARG442
E	NAD501
E	HOH616
F	ARG260
F	HOH618

site_id	AE1
Number of Residues	2
Details	binding site for residue SO4 E 503

Chain	Residue
E	ARG135
E	TRP214

site_id	AE2
Number of Residues	4
Details	binding site for residue PGO E 504

Chain	Residue
E	PHE162
E	ASP171
E	ASP176
E	ARG177

site_id	AE3
Number of Residues	19
Details	binding site for residue NAD F 501

Chain	Residue
F	ILE10
F	GLY11
F	GLY13
F	TYR14
F	VAL15
F	ASP36
F	VAL37
F	ARG41
F	ILE75
F	SER88
F	VAL89
F	ASN90
F	THR91
F	SER130
F	THR131
F	SER275
F	LYS279
F	UPG502
F	HOH624

site_id	AE4
Number of Residues	21
Details	binding site for residue UPG F 502

Chain	Residue
E	ARG260
F	PHE162
F	LEU163
F	ALA164
F	GLU165
F	LYS220
F	ASN224
F	ILE231
F	PHE265
F	LEU266
F	LYS267
F	SER269
F	PHE272
F	GLY273
F	CYS276
F	PHE277
F	PHE338
F	LYS339
F	ARG442
F	NAD501
F	HOH622

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 F 503

Chain	Residue
B	ARG312
F	GLY97
F	MET98
F	GLY99
F	ARG102

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 F 504

Chain	Residue
E	LYS465
F	ARG135
F	TRP214

site_id	AE7
Number of Residues	4
Details	binding site for residue PGO F 505

Chain	Residue
E	ASP258
F	PHE162
F	ASP171
F	ASP176

site_id	AE8
Number of Residues	25
Details	binding site for residue NAD G 501

Chain	Residue
G	ILE10
G	GLY11
G	GLY13
G	TYR14
G	VAL15
G	ASP36
G	VAL37
G	ARG41
G	SER88
G	VAL89
G	ASN90
G	THR91
G	TYR108
G	SER130
G	THR131
G	GLU161
G	GLU165
G	CYS276
G	LYS279
G	ARG346
G	UPG502
G	HOH612
G	HOH617
G	HOH618
G	HOH660

site_id	AE9
Number of Residues	27
Details	binding site for residue UPG G 502

Chain	Residue
G	GLU161
G	PHE162
G	LEU163
G	ALA164
G	GLU165
G	LYS220
G	ASN224
G	ILE231
G	PHE265
G	LEU266
G	LYS267
G	SER269
G	PHE272
G	GLY273
G	CYS276
G	PHE277
G	PHE338
G	LYS339
G	ARG442
G	NAD501
G	HOH612
G	HOH615
G	HOH619
G	HOH623
G	HOH628
G	HOH637
H	ARG260

site_id	AF1
Number of Residues	2
Details	binding site for residue CL G 503

Chain	Residue
G	ARG135
G	TRP214

site_id	AF2
Number of Residues	4
Details	binding site for residue SO4 G 504

Chain	Residue
F	ARG31
F	PHE70
G	ASN263
G	LYS264

site_id	AF3
Number of Residues	5
Details	binding site for residue PGO G 505

Chain	Residue
G	PHE162
G	ASP171
G	ASP176
H	ASP258
H	ARG260

site_id	AF4
Number of Residues	18
Details	binding site for residue NAD H 501

Chain	Residue
H	ILE10
H	GLY11
H	GLY13
H	TYR14
H	VAL15
H	ASP36
H	VAL37
H	ARG41
H	SER88
H	VAL89
H	ASN90
H	THR91
H	TYR108
H	SER130
H	THR131
H	GLU161
H	LYS279
H	UPG502

site_id	AF5
Number of Residues	20
Details	binding site for residue UPG H 502

Chain	Residue
G	ARG260
H	PHE162
H	LEU163
H	ALA164
H	GLU165
H	LYS220
H	ASN224
H	ILE231
H	PHE265
H	LEU266
H	LYS267
H	SER269
H	PHE272
H	GLY273
H	CYS276
H	PHE277
H	PHE338
H	LYS339
H	ARG442
H	NAD501

site_id	AF6
Number of Residues	1
Details	binding site for residue CL H 503

Chain	Residue
H	ARG135

site_id	AF7
Number of Residues	19
Details	binding site for residue NAD I 501

Chain	Residue
I	ILE10
I	GLY11
I	GLY13
I	TYR14
I	VAL15
I	ASP36
I	VAL37
I	ARG41
I	SER88
I	VAL89
I	ASN90
I	THR91
I	TYR108
I	SER130
I	THR131
I	GLU161
I	GLU165
I	UPG502
I	HOH604

site_id	AF8
Number of Residues	20
Details	binding site for residue UPG I 502

Chain	Residue
I	PHE162
I	LEU163
I	ALA164
I	GLU165
I	LYS220
I	ASN224
I	ILE231
I	PHE265
I	LEU266
I	LYS267
I	SER269
I	PHE272
I	GLY273
I	CYS276
I	PHE277
I	PHE338
I	LYS339
I	ARG442
I	NAD501
J	ARG260

site_id	AF9
Number of Residues	2
Details	binding site for residue CL I 503

Chain	Residue
I	GLY99
I	ARG102

site_id	AG1
Number of Residues	1
Details	binding site for residue CL I 504

Chain	Residue
I	ARG135

site_id	AG2
Number of Residues	23
Details	binding site for residue NAD J 501

Chain	Residue
J	ILE10
J	GLY11
J	GLY13
J	TYR14
J	VAL15
J	ASP36
J	VAL37
J	ARG41
J	SER88
J	VAL89
J	ASN90
J	THR91
J	TYR108
J	SER130
J	THR131
J	GLU161
J	GLU165
J	CYS276
J	LYS279
J	ARG346
J	UPG502
J	HOH606
J	HOH616

site_id	AG3
Number of Residues	24
Details	binding site for residue UPG J 502

Chain	Residue
I	ARG260
J	GLU161
J	PHE162
J	LEU163
J	ALA164
J	GLU165
J	LYS220
J	ASN224
J	ILE231
J	PHE265
J	LEU266
J	LYS267
J	SER269
J	PHE272
J	GLY273
J	CYS276
J	PHE277
J	PHE338
J	LYS339
J	ARG442
J	NAD501
J	HOH608
J	HOH611
J	HOH614

site_id	AG4
Number of Residues	1
Details	binding site for residue CL J 503

Chain	Residue
J	ARG135

site_id	AG5
Number of Residues	20
Details	binding site for residue NAD K 501

Chain	Residue
K	ILE10
K	GLY11
K	GLY13
K	TYR14
K	VAL15
K	ASP36
K	VAL37
K	ARG41
K	SER88
K	VAL89
K	ASN90
K	THR91
K	TYR108
K	SER130
K	THR131
K	GLU161
K	LEU163
K	LYS279
K	UPG502
K	HOH628

site_id	AG6
Number of Residues	21
Details	binding site for residue UPG K 502

Chain	Residue
K	PHE162
K	LEU163
K	ALA164
K	GLU165
K	LYS220
K	ASN224
K	ILE231
K	PHE265
K	LEU266
K	LYS267
K	SER269
K	PHE272
K	GLY273
K	CYS276
K	PHE277
K	PHE338
K	LYS339
K	ARG442
K	NAD501
K	HOH632
L	ARG260

site_id	AG7
Number of Residues	1
Details	binding site for residue CL K 503

Chain	Residue
K	GLY56

site_id	AG8
Number of Residues	2
Details	binding site for residue CL K 504

Chain	Residue
K	GLY99
K	ARG102

site_id	AG9
Number of Residues	2
Details	binding site for residue SO4 K 505

Chain	Residue
K	ARG135
K	TRP214

site_id	AH1
Number of Residues	5
Details	binding site for residue PGO K 506

Chain	Residue
K	PHE162
K	ASP171
K	ASP176
K	HOH608
L	ARG260

site_id	AH2
Number of Residues	17
Details	binding site for residue NAD L 501

Chain	Residue
L	ILE10
L	GLY11
L	GLY13
L	TYR14
L	VAL15
L	ASP36
L	ARG41
L	SER88
L	VAL89
L	THR91
L	TYR108
L	SER130
L	THR131
L	GLU161
L	LYS279
L	UPG502
L	HOH603

site_id	AH3
Number of Residues	23
Details	binding site for residue UPG L 502

Chain	Residue
K	ARG260
L	PHE162
L	LEU163
L	ALA164
L	GLU165
L	LYS220
L	ASN224
L	ILE231
L	PHE265
L	LEU266
L	LYS267
L	SER269
L	PHE272
L	GLY273
L	CYS276
L	PHE277
L	PHE338
L	LYS339
L	ARG442
L	NAD501
L	HOH622
L	HOH623
L	HOH625

site_id	AH4
Number of Residues	1
Details	binding site for residue CL L 503

Chain	Residue
L	ARG135

site_id	AH5
Number of Residues	1
Details	binding site for residue CL L 504

Chain	Residue
L	GLY99

site_id	AH6
Number of Residues	5
Details	binding site for residue PGO L 505

Chain	Residue
K	ASP258
K	ARG260
L	PHE162
L	ASP171
L	ASP176

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	264
Details	Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	72
Details	Region: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Region: {"description":"Important for formation of active hexamer structure","evidences":[{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	166
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	180
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)