6C4J
Ligand bound full length hUGDH with A104L substitution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001702 | biological_process | gastrulation with mouth forming second |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| A | 0008152 | biological_process | metabolic process |
| A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0048666 | biological_process | neuron development |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001702 | biological_process | gastrulation with mouth forming second |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| B | 0008152 | biological_process | metabolic process |
| B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0048666 | biological_process | neuron development |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0001702 | biological_process | gastrulation with mouth forming second |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| C | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| C | 0008152 | biological_process | metabolic process |
| C | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| C | 0034214 | biological_process | protein hexamerization |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0048666 | biological_process | neuron development |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0001702 | biological_process | gastrulation with mouth forming second |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| D | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| D | 0008152 | biological_process | metabolic process |
| D | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| D | 0034214 | biological_process | protein hexamerization |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0048666 | biological_process | neuron development |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070062 | cellular_component | extracellular exosome |
| E | 0001702 | biological_process | gastrulation with mouth forming second |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| E | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| E | 0008152 | biological_process | metabolic process |
| E | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| E | 0034214 | biological_process | protein hexamerization |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0048666 | biological_process | neuron development |
| E | 0051287 | molecular_function | NAD binding |
| E | 0070062 | cellular_component | extracellular exosome |
| F | 0001702 | biological_process | gastrulation with mouth forming second |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005654 | cellular_component | nucleoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| F | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| F | 0008152 | biological_process | metabolic process |
| F | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| F | 0034214 | biological_process | protein hexamerization |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0048666 | biological_process | neuron development |
| F | 0051287 | molecular_function | NAD binding |
| F | 0070062 | cellular_component | extracellular exosome |
| G | 0001702 | biological_process | gastrulation with mouth forming second |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0005654 | cellular_component | nucleoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| G | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| G | 0008152 | biological_process | metabolic process |
| G | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| G | 0034214 | biological_process | protein hexamerization |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0048666 | biological_process | neuron development |
| G | 0051287 | molecular_function | NAD binding |
| G | 0070062 | cellular_component | extracellular exosome |
| H | 0001702 | biological_process | gastrulation with mouth forming second |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| H | 0005634 | cellular_component | nucleus |
| H | 0005654 | cellular_component | nucleoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| H | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| H | 0008152 | biological_process | metabolic process |
| H | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| H | 0034214 | biological_process | protein hexamerization |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0048666 | biological_process | neuron development |
| H | 0051287 | molecular_function | NAD binding |
| H | 0070062 | cellular_component | extracellular exosome |
| I | 0001702 | biological_process | gastrulation with mouth forming second |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| I | 0005634 | cellular_component | nucleus |
| I | 0005654 | cellular_component | nucleoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| I | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| I | 0008152 | biological_process | metabolic process |
| I | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| I | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| I | 0034214 | biological_process | protein hexamerization |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0048666 | biological_process | neuron development |
| I | 0051287 | molecular_function | NAD binding |
| I | 0070062 | cellular_component | extracellular exosome |
| J | 0001702 | biological_process | gastrulation with mouth forming second |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| J | 0005634 | cellular_component | nucleus |
| J | 0005654 | cellular_component | nucleoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| J | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| J | 0008152 | biological_process | metabolic process |
| J | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| J | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| J | 0034214 | biological_process | protein hexamerization |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0048666 | biological_process | neuron development |
| J | 0051287 | molecular_function | NAD binding |
| J | 0070062 | cellular_component | extracellular exosome |
| K | 0001702 | biological_process | gastrulation with mouth forming second |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| K | 0005634 | cellular_component | nucleus |
| K | 0005654 | cellular_component | nucleoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| K | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| K | 0008152 | biological_process | metabolic process |
| K | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| K | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| K | 0034214 | biological_process | protein hexamerization |
| K | 0042802 | molecular_function | identical protein binding |
| K | 0048666 | biological_process | neuron development |
| K | 0051287 | molecular_function | NAD binding |
| K | 0070062 | cellular_component | extracellular exosome |
| L | 0001702 | biological_process | gastrulation with mouth forming second |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| L | 0005634 | cellular_component | nucleus |
| L | 0005654 | cellular_component | nucleoplasm |
| L | 0005829 | cellular_component | cytosol |
| L | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| L | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| L | 0008152 | biological_process | metabolic process |
| L | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| L | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| L | 0034214 | biological_process | protein hexamerization |
| L | 0042802 | molecular_function | identical protein binding |
| L | 0048666 | biological_process | neuron development |
| L | 0051287 | molecular_function | NAD binding |
| L | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue NAD A 501 |
| Chain | Residue |
| A | GLY13 |
| A | GLU161 |
| A | CYS276 |
| A | LYS279 |
| A | UPG502 |
| A | TYR14 |
| A | VAL15 |
| A | VAL89 |
| A | ASN90 |
| A | THR91 |
| A | TYR108 |
| A | CYS112 |
| A | THR131 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue UPG A 502 |
| Chain | Residue |
| A | PHE162 |
| A | LEU163 |
| A | ALA164 |
| A | GLU165 |
| A | LYS220 |
| A | ASN224 |
| A | ILE231 |
| A | PHE265 |
| A | LEU266 |
| A | LYS267 |
| A | SER269 |
| A | PHE272 |
| A | GLY273 |
| A | CYS276 |
| A | PHE277 |
| A | PHE338 |
| A | LYS339 |
| A | ARG442 |
| A | NAD501 |
| A | HOH610 |
| A | HOH614 |
| A | HOH615 |
| B | ARG260 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | ARG135 |
| A | TRP214 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue NAD B 501 |
| Chain | Residue |
| B | ILE10 |
| B | GLY11 |
| B | GLY13 |
| B | TYR14 |
| B | VAL15 |
| B | ASP36 |
| B | VAL37 |
| B | ARG41 |
| B | ILE75 |
| B | SER88 |
| B | VAL89 |
| B | ASN90 |
| B | THR91 |
| B | TYR108 |
| B | SER130 |
| B | THR131 |
| B | GLU161 |
| B | LYS279 |
| B | UPG502 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue UPG B 502 |
| Chain | Residue |
| A | ARG260 |
| B | PHE162 |
| B | LEU163 |
| B | ALA164 |
| B | GLU165 |
| B | LYS220 |
| B | ASN224 |
| B | ILE231 |
| B | PHE265 |
| B | LEU266 |
| B | LYS267 |
| B | SER269 |
| B | PHE272 |
| B | GLY273 |
| B | CYS276 |
| B | PHE277 |
| B | PHE338 |
| B | LYS339 |
| B | ARG442 |
| B | NAD501 |
| B | HOH604 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 503 |
| Chain | Residue |
| B | GLY99 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | ARG135 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for residue NAD C 501 |
| Chain | Residue |
| C | ILE10 |
| C | GLY11 |
| C | GLY13 |
| C | TYR14 |
| C | VAL15 |
| C | ASP36 |
| C | VAL37 |
| C | ARG41 |
| C | VAL89 |
| C | ASN90 |
| C | THR91 |
| C | TYR108 |
| C | SER130 |
| C | THR131 |
| C | GLU161 |
| C | LYS279 |
| C | UPG502 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for residue UPG C 502 |
| Chain | Residue |
| C | GLU165 |
| C | LYS220 |
| C | ASN224 |
| C | ILE231 |
| C | PHE265 |
| C | LEU266 |
| C | LYS267 |
| C | SER269 |
| C | PHE272 |
| C | GLY273 |
| C | CYS276 |
| C | PHE277 |
| C | PHE338 |
| C | LYS339 |
| C | ARG442 |
| C | NAD501 |
| C | HOH616 |
| D | ARG260 |
| C | PHE162 |
| C | LEU163 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 503 |
| Chain | Residue |
| C | ARG135 |
| C | TRP214 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue NAD D 501 |
| Chain | Residue |
| D | ILE10 |
| D | GLY11 |
| D | GLY13 |
| D | TYR14 |
| D | VAL15 |
| D | ASP36 |
| D | VAL37 |
| D | ARG41 |
| D | SER88 |
| D | VAL89 |
| D | ASN90 |
| D | THR91 |
| D | TYR108 |
| D | SER130 |
| D | THR131 |
| D | GLU161 |
| D | LYS279 |
| D | UPG502 |
| site_id | AD3 |
| Number of Residues | 23 |
| Details | binding site for residue UPG D 502 |
| Chain | Residue |
| C | ARG260 |
| D | PHE162 |
| D | LEU163 |
| D | ALA164 |
| D | GLU165 |
| D | LYS220 |
| D | ASN224 |
| D | ILE231 |
| D | PHE265 |
| D | LEU266 |
| D | LYS267 |
| D | SER269 |
| D | PHE272 |
| D | GLY273 |
| D | CYS276 |
| D | PHE277 |
| D | PHE338 |
| D | LYS339 |
| D | ARG442 |
| D | NAD501 |
| D | HOH606 |
| D | HOH611 |
| D | HOH624 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 503 |
| Chain | Residue |
| D | GLY99 |
| D | ARG102 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 504 |
| Chain | Residue |
| D | ASN263 |
| D | LYS264 |
| K | ARG31 |
| K | PHE70 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 505 |
| Chain | Residue |
| C | LYS465 |
| D | ARG135 |
| D | TRP214 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue PGO D 506 |
| Chain | Residue |
| C | ASP258 |
| C | ARG260 |
| D | ASP171 |
| D | ASP176 |
| D | ARG177 |
| site_id | AD8 |
| Number of Residues | 21 |
| Details | binding site for residue NAD E 501 |
| Chain | Residue |
| E | ILE10 |
| E | GLY11 |
| E | GLY13 |
| E | TYR14 |
| E | VAL15 |
| E | ASP36 |
| E | VAL37 |
| E | ARG41 |
| E | SER88 |
| E | VAL89 |
| E | ASN90 |
| E | THR91 |
| E | TYR108 |
| E | SER130 |
| E | THR131 |
| E | GLU161 |
| E | LYS279 |
| E | UPG502 |
| E | HOH633 |
| E | HOH634 |
| E | HOH639 |
| site_id | AD9 |
| Number of Residues | 22 |
| Details | binding site for residue UPG E 502 |
| Chain | Residue |
| E | PHE162 |
| E | LEU163 |
| E | ALA164 |
| E | GLU165 |
| E | LYS220 |
| E | ASN224 |
| E | ILE231 |
| E | PHE265 |
| E | LEU266 |
| E | LYS267 |
| E | SER269 |
| E | PHE272 |
| E | GLY273 |
| E | CYS276 |
| E | PHE277 |
| E | PHE338 |
| E | LYS339 |
| E | ARG442 |
| E | NAD501 |
| E | HOH616 |
| F | ARG260 |
| F | HOH618 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 E 503 |
| Chain | Residue |
| E | ARG135 |
| E | TRP214 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue PGO E 504 |
| Chain | Residue |
| E | PHE162 |
| E | ASP171 |
| E | ASP176 |
| E | ARG177 |
| site_id | AE3 |
| Number of Residues | 19 |
| Details | binding site for residue NAD F 501 |
| Chain | Residue |
| F | ILE10 |
| F | GLY11 |
| F | GLY13 |
| F | TYR14 |
| F | VAL15 |
| F | ASP36 |
| F | VAL37 |
| F | ARG41 |
| F | ILE75 |
| F | SER88 |
| F | VAL89 |
| F | ASN90 |
| F | THR91 |
| F | SER130 |
| F | THR131 |
| F | SER275 |
| F | LYS279 |
| F | UPG502 |
| F | HOH624 |
| site_id | AE4 |
| Number of Residues | 21 |
| Details | binding site for residue UPG F 502 |
| Chain | Residue |
| E | ARG260 |
| F | PHE162 |
| F | LEU163 |
| F | ALA164 |
| F | GLU165 |
| F | LYS220 |
| F | ASN224 |
| F | ILE231 |
| F | PHE265 |
| F | LEU266 |
| F | LYS267 |
| F | SER269 |
| F | PHE272 |
| F | GLY273 |
| F | CYS276 |
| F | PHE277 |
| F | PHE338 |
| F | LYS339 |
| F | ARG442 |
| F | NAD501 |
| F | HOH622 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 F 503 |
| Chain | Residue |
| B | ARG312 |
| F | GLY97 |
| F | MET98 |
| F | GLY99 |
| F | ARG102 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 F 504 |
| Chain | Residue |
| E | LYS465 |
| F | ARG135 |
| F | TRP214 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue PGO F 505 |
| Chain | Residue |
| E | ASP258 |
| F | PHE162 |
| F | ASP171 |
| F | ASP176 |
| site_id | AE8 |
| Number of Residues | 25 |
| Details | binding site for residue NAD G 501 |
| Chain | Residue |
| G | ILE10 |
| G | GLY11 |
| G | GLY13 |
| G | TYR14 |
| G | VAL15 |
| G | ASP36 |
| G | VAL37 |
| G | ARG41 |
| G | SER88 |
| G | VAL89 |
| G | ASN90 |
| G | THR91 |
| G | TYR108 |
| G | SER130 |
| G | THR131 |
| G | GLU161 |
| G | GLU165 |
| G | CYS276 |
| G | LYS279 |
| G | ARG346 |
| G | UPG502 |
| G | HOH612 |
| G | HOH617 |
| G | HOH618 |
| G | HOH660 |
| site_id | AE9 |
| Number of Residues | 27 |
| Details | binding site for residue UPG G 502 |
| Chain | Residue |
| G | GLU161 |
| G | PHE162 |
| G | LEU163 |
| G | ALA164 |
| G | GLU165 |
| G | LYS220 |
| G | ASN224 |
| G | ILE231 |
| G | PHE265 |
| G | LEU266 |
| G | LYS267 |
| G | SER269 |
| G | PHE272 |
| G | GLY273 |
| G | CYS276 |
| G | PHE277 |
| G | PHE338 |
| G | LYS339 |
| G | ARG442 |
| G | NAD501 |
| G | HOH612 |
| G | HOH615 |
| G | HOH619 |
| G | HOH623 |
| G | HOH628 |
| G | HOH637 |
| H | ARG260 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue CL G 503 |
| Chain | Residue |
| G | ARG135 |
| G | TRP214 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 G 504 |
| Chain | Residue |
| F | ARG31 |
| F | PHE70 |
| G | ASN263 |
| G | LYS264 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue PGO G 505 |
| Chain | Residue |
| G | PHE162 |
| G | ASP171 |
| G | ASP176 |
| H | ASP258 |
| H | ARG260 |
| site_id | AF4 |
| Number of Residues | 18 |
| Details | binding site for residue NAD H 501 |
| Chain | Residue |
| H | ILE10 |
| H | GLY11 |
| H | GLY13 |
| H | TYR14 |
| H | VAL15 |
| H | ASP36 |
| H | VAL37 |
| H | ARG41 |
| H | SER88 |
| H | VAL89 |
| H | ASN90 |
| H | THR91 |
| H | TYR108 |
| H | SER130 |
| H | THR131 |
| H | GLU161 |
| H | LYS279 |
| H | UPG502 |
| site_id | AF5 |
| Number of Residues | 20 |
| Details | binding site for residue UPG H 502 |
| Chain | Residue |
| G | ARG260 |
| H | PHE162 |
| H | LEU163 |
| H | ALA164 |
| H | GLU165 |
| H | LYS220 |
| H | ASN224 |
| H | ILE231 |
| H | PHE265 |
| H | LEU266 |
| H | LYS267 |
| H | SER269 |
| H | PHE272 |
| H | GLY273 |
| H | CYS276 |
| H | PHE277 |
| H | PHE338 |
| H | LYS339 |
| H | ARG442 |
| H | NAD501 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue CL H 503 |
| Chain | Residue |
| H | ARG135 |
| site_id | AF7 |
| Number of Residues | 19 |
| Details | binding site for residue NAD I 501 |
| Chain | Residue |
| I | ILE10 |
| I | GLY11 |
| I | GLY13 |
| I | TYR14 |
| I | VAL15 |
| I | ASP36 |
| I | VAL37 |
| I | ARG41 |
| I | SER88 |
| I | VAL89 |
| I | ASN90 |
| I | THR91 |
| I | TYR108 |
| I | SER130 |
| I | THR131 |
| I | GLU161 |
| I | GLU165 |
| I | UPG502 |
| I | HOH604 |
| site_id | AF8 |
| Number of Residues | 20 |
| Details | binding site for residue UPG I 502 |
| Chain | Residue |
| I | PHE162 |
| I | LEU163 |
| I | ALA164 |
| I | GLU165 |
| I | LYS220 |
| I | ASN224 |
| I | ILE231 |
| I | PHE265 |
| I | LEU266 |
| I | LYS267 |
| I | SER269 |
| I | PHE272 |
| I | GLY273 |
| I | CYS276 |
| I | PHE277 |
| I | PHE338 |
| I | LYS339 |
| I | ARG442 |
| I | NAD501 |
| J | ARG260 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue CL I 503 |
| Chain | Residue |
| I | GLY99 |
| I | ARG102 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue CL I 504 |
| Chain | Residue |
| I | ARG135 |
| site_id | AG2 |
| Number of Residues | 23 |
| Details | binding site for residue NAD J 501 |
| Chain | Residue |
| J | ILE10 |
| J | GLY11 |
| J | GLY13 |
| J | TYR14 |
| J | VAL15 |
| J | ASP36 |
| J | VAL37 |
| J | ARG41 |
| J | SER88 |
| J | VAL89 |
| J | ASN90 |
| J | THR91 |
| J | TYR108 |
| J | SER130 |
| J | THR131 |
| J | GLU161 |
| J | GLU165 |
| J | CYS276 |
| J | LYS279 |
| J | ARG346 |
| J | UPG502 |
| J | HOH606 |
| J | HOH616 |
| site_id | AG3 |
| Number of Residues | 24 |
| Details | binding site for residue UPG J 502 |
| Chain | Residue |
| I | ARG260 |
| J | GLU161 |
| J | PHE162 |
| J | LEU163 |
| J | ALA164 |
| J | GLU165 |
| J | LYS220 |
| J | ASN224 |
| J | ILE231 |
| J | PHE265 |
| J | LEU266 |
| J | LYS267 |
| J | SER269 |
| J | PHE272 |
| J | GLY273 |
| J | CYS276 |
| J | PHE277 |
| J | PHE338 |
| J | LYS339 |
| J | ARG442 |
| J | NAD501 |
| J | HOH608 |
| J | HOH611 |
| J | HOH614 |
| site_id | AG4 |
| Number of Residues | 1 |
| Details | binding site for residue CL J 503 |
| Chain | Residue |
| J | ARG135 |
| site_id | AG5 |
| Number of Residues | 20 |
| Details | binding site for residue NAD K 501 |
| Chain | Residue |
| K | ILE10 |
| K | GLY11 |
| K | GLY13 |
| K | TYR14 |
| K | VAL15 |
| K | ASP36 |
| K | VAL37 |
| K | ARG41 |
| K | SER88 |
| K | VAL89 |
| K | ASN90 |
| K | THR91 |
| K | TYR108 |
| K | SER130 |
| K | THR131 |
| K | GLU161 |
| K | LEU163 |
| K | LYS279 |
| K | UPG502 |
| K | HOH628 |
| site_id | AG6 |
| Number of Residues | 21 |
| Details | binding site for residue UPG K 502 |
| Chain | Residue |
| K | PHE162 |
| K | LEU163 |
| K | ALA164 |
| K | GLU165 |
| K | LYS220 |
| K | ASN224 |
| K | ILE231 |
| K | PHE265 |
| K | LEU266 |
| K | LYS267 |
| K | SER269 |
| K | PHE272 |
| K | GLY273 |
| K | CYS276 |
| K | PHE277 |
| K | PHE338 |
| K | LYS339 |
| K | ARG442 |
| K | NAD501 |
| K | HOH632 |
| L | ARG260 |
| site_id | AG7 |
| Number of Residues | 1 |
| Details | binding site for residue CL K 503 |
| Chain | Residue |
| K | GLY56 |
| site_id | AG8 |
| Number of Residues | 2 |
| Details | binding site for residue CL K 504 |
| Chain | Residue |
| K | GLY99 |
| K | ARG102 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 K 505 |
| Chain | Residue |
| K | ARG135 |
| K | TRP214 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue PGO K 506 |
| Chain | Residue |
| K | PHE162 |
| K | ASP171 |
| K | ASP176 |
| K | HOH608 |
| L | ARG260 |
| site_id | AH2 |
| Number of Residues | 17 |
| Details | binding site for residue NAD L 501 |
| Chain | Residue |
| L | ILE10 |
| L | GLY11 |
| L | GLY13 |
| L | TYR14 |
| L | VAL15 |
| L | ASP36 |
| L | ARG41 |
| L | SER88 |
| L | VAL89 |
| L | THR91 |
| L | TYR108 |
| L | SER130 |
| L | THR131 |
| L | GLU161 |
| L | LYS279 |
| L | UPG502 |
| L | HOH603 |
| site_id | AH3 |
| Number of Residues | 23 |
| Details | binding site for residue UPG L 502 |
| Chain | Residue |
| K | ARG260 |
| L | PHE162 |
| L | LEU163 |
| L | ALA164 |
| L | GLU165 |
| L | LYS220 |
| L | ASN224 |
| L | ILE231 |
| L | PHE265 |
| L | LEU266 |
| L | LYS267 |
| L | SER269 |
| L | PHE272 |
| L | GLY273 |
| L | CYS276 |
| L | PHE277 |
| L | PHE338 |
| L | LYS339 |
| L | ARG442 |
| L | NAD501 |
| L | HOH622 |
| L | HOH623 |
| L | HOH625 |
| site_id | AH4 |
| Number of Residues | 1 |
| Details | binding site for residue CL L 503 |
| Chain | Residue |
| L | ARG135 |
| site_id | AH5 |
| Number of Residues | 1 |
| Details | binding site for residue CL L 504 |
| Chain | Residue |
| L | GLY99 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue PGO L 505 |
| Chain | Residue |
| K | ASP258 |
| K | ARG260 |
| L | PHE162 |
| L | ASP171 |
| L | ASP176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22123821 |
| Chain | Residue | Details |
| A | GLU161 | |
| A | LYS220 | |
| B | GLU161 | |
| B | LYS220 | |
| C | GLU161 | |
| C | LYS220 | |
| D | GLU161 | |
| D | LYS220 | |
| E | GLU161 | |
| E | LYS220 | |
| F | GLU161 | |
| F | LYS220 | |
| G | GLU161 | |
| G | LYS220 | |
| H | GLU161 | |
| H | LYS220 | |
| I | GLU161 | |
| I | LYS220 | |
| J | GLU161 | |
| J | LYS220 | |
| K | GLU161 | |
| K | LYS220 | |
| L | GLU161 | |
| L | LYS220 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 |
| Chain | Residue | Details |
| F | CYS276 | |
| G | CYS276 | |
| H | CYS276 | |
| I | CYS276 | |
| J | CYS276 | |
| K | CYS276 | |
| L | CYS276 | |
| A | CYS276 | |
| B | CYS276 | |
| C | CYS276 | |
| D | CYS276 | |
| E | CYS276 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
| Chain | Residue | Details |
| E | CYS276 | |
| F | GLY11 | |
| F | ASP36 | |
| F | ARG41 | |
| F | VAL89 | |
| F | CYS276 | |
| G | GLY11 | |
| G | ASP36 | |
| G | ARG41 | |
| G | VAL89 | |
| G | CYS276 | |
| H | GLY11 | |
| H | ASP36 | |
| H | ARG41 | |
| H | VAL89 | |
| H | CYS276 | |
| I | GLY11 | |
| I | ASP36 | |
| I | ARG41 | |
| I | VAL89 | |
| I | CYS276 | |
| J | GLY11 | |
| J | ASP36 | |
| J | ARG41 | |
| J | VAL89 | |
| J | CYS276 | |
| K | GLY11 | |
| K | ASP36 | |
| K | ARG41 | |
| K | VAL89 | |
| K | CYS276 | |
| L | GLY11 | |
| L | ASP36 | |
| L | ARG41 | |
| L | VAL89 | |
| L | CYS276 | |
| C | ARG41 | |
| C | VAL89 | |
| C | CYS276 | |
| D | GLY11 | |
| D | ASP36 | |
| D | ARG41 | |
| D | VAL89 | |
| D | CYS276 | |
| E | GLY11 | |
| E | ASP36 | |
| E | ARG41 | |
| E | VAL89 | |
| A | GLY11 | |
| A | ASP36 | |
| A | ARG41 | |
| A | VAL89 | |
| A | CYS276 | |
| B | GLY11 | |
| B | ASP36 | |
| B | ARG41 | |
| B | VAL89 | |
| B | CYS276 | |
| C | GLY11 | |
| C | ASP36 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 |
| Chain | Residue | Details |
| F | SER130 | |
| G | SER130 | |
| H | SER130 | |
| I | SER130 | |
| J | SER130 | |
| K | SER130 | |
| L | SER130 | |
| A | SER130 | |
| B | SER130 | |
| C | SER130 | |
| D | SER130 | |
| E | SER130 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
| Chain | Residue | Details |
| G | GLU161 | |
| G | LYS220 | |
| G | LYS267 | |
| G | PHE338 | |
| H | GLU161 | |
| H | LYS220 | |
| H | LYS267 | |
| H | PHE338 | |
| I | GLU161 | |
| I | LYS220 | |
| I | LYS267 | |
| I | PHE338 | |
| J | GLU161 | |
| J | LYS220 | |
| J | LYS267 | |
| J | PHE338 | |
| K | GLU161 | |
| K | LYS220 | |
| K | LYS267 | |
| K | PHE338 | |
| L | GLU161 | |
| L | LYS220 | |
| L | LYS267 | |
| L | PHE338 | |
| C | LYS220 | |
| C | LYS267 | |
| C | PHE338 | |
| D | GLU161 | |
| D | LYS220 | |
| A | GLU161 | |
| A | LYS220 | |
| A | LYS267 | |
| A | PHE338 | |
| B | GLU161 | |
| B | LYS220 | |
| B | LYS267 | |
| B | PHE338 | |
| C | GLU161 | |
| D | LYS267 | |
| D | PHE338 | |
| E | GLU161 | |
| E | LYS220 | |
| E | LYS267 | |
| E | PHE338 | |
| F | GLU161 | |
| F | LYS220 | |
| F | LYS267 | |
| F | PHE338 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 |
| Chain | Residue | Details |
| E | GLU165 | |
| F | GLU165 | |
| G | GLU165 | |
| A | GLU165 | |
| B | GLU165 | |
| C | GLU165 | |
| D | GLU165 | |
| H | GLU165 | |
| I | GLU165 | |
| J | GLU165 | |
| K | GLU165 | |
| L | GLU165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH |
| Chain | Residue | Details |
| E | ARG260 | |
| F | ARG260 | |
| G | ARG260 | |
| A | ARG260 | |
| B | ARG260 | |
| C | ARG260 | |
| D | ARG260 | |
| H | ARG260 | |
| I | ARG260 | |
| J | ARG260 | |
| K | ARG260 | |
| L | ARG260 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
| Chain | Residue | Details |
| A | ARG346 | |
| B | ARG346 | |
| C | ARG346 | |
| D | ARG346 | |
| E | ARG346 | |
| F | ARG346 | |
| G | ARG346 | |
| H | ARG346 | |
| I | ARG346 | |
| J | ARG346 | |
| K | ARG346 | |
| L | ARG346 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
| Chain | Residue | Details |
| A | ARG442 | |
| B | ARG442 | |
| C | ARG442 | |
| D | ARG442 | |
| E | ARG442 | |
| F | ARG442 | |
| G | ARG442 | |
| H | ARG442 | |
| I | ARG442 | |
| J | ARG442 | |
| K | ARG442 | |
| L | ARG442 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS107 | |
| B | LYS107 | |
| C | LYS107 | |
| D | LYS107 | |
| E | LYS107 | |
| F | LYS107 | |
| G | LYS107 | |
| H | LYS107 | |
| I | LYS107 | |
| J | LYS107 | |
| K | LYS107 | |
| L | LYS107 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER476 | |
| B | SER476 | |
| C | SER476 | |
| D | SER476 | |
| E | SER476 | |
| F | SER476 | |
| G | SER476 | |
| H | SER476 | |
| I | SER476 | |
| J | SER476 | |
| K | SER476 | |
| L | SER476 |
