6BKJ

Crystal Structure of Human Calpain-3 Protease Core in Complex with Leupeptin

Summary for 6BKJ

• Entry DOI: 10.2210/pdb6bkj/pdb
• Related: 6BJD
• Related PRD ID: PRD_000216
• Descriptor: Calpain-3, Leupeptin, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: calcium binding, cysteine protease, calpain, p94, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 179863.64

Authors

Ye, Q.,Campbell, R.L.,Davies, P.L. (deposition date: 2017-11-08, release date: 2018-02-07, Last modification date: 2023-10-04)

• Primary citation: Ye, Q.,Campbell, R.L.,Davies, P.L.; Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.; J. Biol. Chem., 293:4056-4070, 2018; PubMed: 29382717; DOI: 10.1074/jbc.RA117.001097

Experimental method

X-RAY DIFFRACTION (3.2 Å)