6ALB

CREBBP bromodomain in complex with Cpd 30 (1-(3-(3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)

Summary for 6ALB

• Entry DOI: 10.2210/pdb6alb/pdb
• Related: 6ALC
• Descriptor: CREB-binding protein, ZINC ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• Functional Keywords: crebbp, bromodomain, small molecule inhibitor, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28459.51

Authors

Murray, J.M. (deposition date: 2017-08-07, release date: 2018-10-17, Last modification date: 2023-10-04)

• Primary citation: Murray, J.M.; Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300; To be published,

Experimental method

X-RAY DIFFRACTION (2.053 Å)