6ALB

CREBBP bromodomain in complex with Cpd 30 (1-(3-(3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1401

Chain	Residue
A	CYS1199
A	CYS1200
A	HIS1291
A	CYS1294

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1402

Chain	Residue
A	CYS1283
A	CYS1286
A	CYS1308
A	CYS1311

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1403

Chain	Residue
A	CYS1219
A	CYS1237
A	CYS1240
A	CYS1213

---

site_id	AC4
Number of Residues	5
Details	binding site for residue B3P A 1404

Chain	Residue
A	ASN1162
A	TRP1165
A	TYR1204
A	ASP1273
A	LEU1275

---

site_id	AC5
Number of Residues	6
Details	binding site for residue BKJ A 1405

Chain	Residue
A	LEU1109
A	PRO1110
A	GLN1113
A	ASN1168
A	PHE1177
A	HOH1522

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	46
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---