6ALB
CREBBP bromodomain in complex with Cpd 30 (1-(3-(3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CREB-binding protein | polymer | 233 | 27524.4 | 1 | UniProt (Q92793) Pfam (PF00439) Pfam (PF06001) | Homo sapiens (Human) | |
| 2 | B, C, D (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E (A) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 4 | F (A) | 1-{3-[3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one | non-polymer | 456.5 | 1 | Chemie (BKJ) | |||
| 5 | G (A) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 1081 - 1312 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ser 1080 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27524.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 935.1 | |
| All* | Total formula weight | 28459.5 |
