6ALC
CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Summary for 6ALC
Entry DOI | 10.2210/pdb6alc/pdb |
Related | 6ALB |
Descriptor | CREB-binding protein, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | crebbp, bromodomain, small molecule inhibitor, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 27565.55 |
Authors | Murray, J.M. (deposition date: 2017-08-07, release date: 2018-08-08, Last modification date: 2023-10-04) |
Primary citation | Lai, K.W.,Romero, F.A.,Tsui, V.,Beresini, M.H.,de Leon Boenig, G.,Bronner, S.M.,Chen, K.,Chen, Z.,Choo, E.F.,Crawford, T.D.,Cyr, P.,Kaufman, S.,Li, Y.,Liao, J.,Liu, W.,Ly, J.,Murray, J.,Shen, W.,Wai, J.,Wang, F.,Zhu, C.,Zhu, X.,Magnuson, S. Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. Bioorg. Med. Chem. Lett., 28:15-23, 2018 Cited by PubMed: 29169673DOI: 10.1016/j.bmcl.2017.11.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.391 Å) |
Structure validation
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