6ALC
CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CREB-binding protein | polymer | 114 | 13545.5 | 2 | UniProt (Q92793) Pfam (PF00439) | Homo sapiens (Human) | |
| 2 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | E (B) | 1-[1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]ethan-1-one | non-polymer | 334.4 | 1 | Chemie (BKD) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A, B: 1085 - 1196 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ala 1083 | - | expression tag |
| Ala 1084 | - | expression tag |
| Ala 1195 | Ser 1195 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27090.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 474.6 | |
| All* | Total formula weight | 27565.6 |
