6WVZ
Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET
Summary for 6WVZ
Entry DOI | 10.2210/pdb6wvz/pdb |
Descriptor | Heavy Chain of anti-MET Fab of amivantamab, Light Chain of anti-MET Fab of amivantamab, Hepatocyte growth factor receptor, ... (8 entities in total) |
Functional Keywords | antigen-fab complex, semaphorin domain, plexin semaphorin integrin cysteine-rich domain, antitumor protein, transferase-immune system complex, transferase/immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 110928.31 |
Authors | Cardoso, R.M.F. (deposition date: 2020-05-07, release date: 2021-04-28, Last modification date: 2023-10-18) |
Primary citation | Neijssen, J.,Cardoso, R.M.F.,Chevalier, K.M.,Wiegman, L.,Valerius, T.,Anderson, G.M.,Moores, S.L.,Schuurman, J.,Parren, P.W.H.I.,Strohl, W.R.,Chiu, M.L. Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET. J.Biol.Chem., 296:100641-100641, 2021 Cited by PubMed: 33839159DOI: 10.1016/j.jbc.2021.100641 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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