6V14
Crystal structure of the bromodomain of human BRD9 bound to TP472
Summary for 6V14
Entry DOI | 10.2210/pdb6v14/pdb |
Descriptor | Bromodomain-containing protein 9, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | brd9, mswi/snf, baf, non-bet, brd, tp472, tp-472, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14645.22 |
Authors | Karim, M.R.,Chan, A.,Schonbrunn, E. (deposition date: 2019-11-19, release date: 2020-03-11, Last modification date: 2023-10-11) |
Primary citation | Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63:3227-3237, 2020 Cited by PubMed: 32091206DOI: 10.1021/acs.jmedchem.9b01980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report