6F5H
Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor
Summary for 6F5H
Entry DOI | 10.2210/pdb6f5h/pdb |
Related | 5N9R 5N9T |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, SULFATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | usp7, reversible, inhibitor, selective, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q93009 |
Total number of polymer chains | 2 |
Total formula weight | 84327.20 |
Authors | Harrison, T.,Gavory, G.,O'Dowd, C.,Helm, M.,Flasz, J.,Dossang, A.,Hughes, C.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Barker, O.,Miel, H.,Feutron-Burton, S.,Rountree, J.S.S. (deposition date: 2017-12-01, release date: 2018-04-11, Last modification date: 2024-05-08) |
Primary citation | O'Dowd, C.R.,Helm, M.D.,Rountree, J.S.S.,Flasz, J.T.,Arkoudis, E.,Miel, H.,Hewitt, P.R.,Jordan, L.,Barker, O.,Hughes, C.,Rozycka, E.,Cassidy, E.,McClelland, K.,Odrzywol, E.,Page, N.,Feutren-Burton, S.,Dvorkin, S.,Gavory, G.,Harrison, T. Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors. ACS Med Chem Lett, 9:238-243, 2018 Cited by PubMed: 29541367DOI: 10.1021/acsmedchemlett.7b00512 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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