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5ZQR

Tankyrase-2 in complex with compound 40c

Summary for 5ZQR
Entry DOI10.2210/pdb5zqr/pdb
DescriptorTankyrase-2, ZINC ION, 2-[4,6-difluoro-1-(2-hydroxyethyl)-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, ... (7 entities in total)
Functional Keywordstankyrase, parp, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight25367.78
Authors
Niwa, H.,Shirai, F.,Sato, S.,Yoshimoto, N.,Tsumura, T.,Okue, M.,Shirouzu, M.,Seimiya, H.,Umehara, T. (deposition date: 2018-04-19, release date: 2019-04-03, Last modification date: 2023-11-22)
Primary citationShirai, F.,Tsumura, T.,Yashiroda, Y.,Yuki, H.,Niwa, H.,Sato, S.,Chikada, T.,Koda, Y.,Washizuka, K.,Yoshimoto, N.,Abe, M.,Onuki, T.,Mazaki, Y.,Hirama, C.,Fukami, T.,Watanabe, H.,Honma, T.,Umehara, T.,Shirouzu, M.,Okue, M.,Kano, Y.,Watanabe, T.,Kitamura, K.,Shitara, E.,Muramatsu, Y.,Yoshida, H.,Mizutani, A.,Seimiya, H.,Yoshida, M.,Koyama, H.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62:3407-3427, 2019
Cited by
PubMed: 30883102
DOI: 10.1021/acs.jmedchem.8b01888
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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