5YPL
Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EP complex
Summary for 5YPL
Entry DOI | 10.2210/pdb5ypl/pdb |
Descriptor | Metallo-beta-lactamase NDM-1, ZINC ION, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, ... (6 entities in total) |
Functional Keywords | ndm-1, imipenem, ep complex, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 52291.51 |
Authors | |
Primary citation | Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat Commun, 8:2242-2242, 2017 Cited by PubMed: 29269938DOI: 10.1038/s41467-017-02339-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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