5VLP

PCSK9 complex with LDLR antagonist peptide and Fab7G7

Summary for 5VLP

Entry DOI	10.2210/pdb5vlp/pdb
Related	5VL7 5VLA 5VLH 5VLK 5VLL
Descriptor	Proprotein convertase subtilisin/kexin type 9, Fab7G7 heavy chain, Fab7G7 light chain, ... (6 entities in total)
Functional Keywords	immunoglobulin, proprotein convertase, antagonist, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	125318.69
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2023-11-15)
Primary citation	Zhang, Y.,Ultsch, M.,Skelton, N.J.,Burdick, D.J.,Beresini, M.H.,Li, W.,Kong-Beltran, M.,Peterson, A.,Quinn, J.,Chiu, C.,Wu, Y.,Shia, S.,Moran, P.,Di Lello, P.,Eigenbrot, C.,Kirchhofer, D. Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24:848-856, 2017 Cited by PubMed: 28825733 DOI: 10.1038/nsmb.3453 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation