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5VD2

crystal structure of human WEE1 kinase domain in complex with PF-03814735

Summary for 5VD2
Entry DOI10.2210/pdb5vd2/pdb
Related5VC3 5VC4 5VC5 5VC6 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA
DescriptorWee1-like protein kinase, N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordskinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight33081.26
Authors
Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-04-01, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citationZhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E.
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
J. Med. Chem., 60:7863-7875, 2017
Cited by
PubMed: 28792760
DOI: 10.1021/acs.jmedchem.7b00996
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

217705

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