5VC4

Crystal structure of HUMAN WEE1 KINASE domain in complex with Bosutinib-isomer

Summary for 5VC4

Entry DOI	10.2210/pdb5vc4/pdb
Related	5VC3 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA
Descriptor	Wee1-like protein kinase, 4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	kinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33066.32
Authors	Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-03-30, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J. Med. Chem., 60:7863-7875, 2017 Cited by PubMed: 28792760 DOI: 10.1021/acs.jmedchem.7b00996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation