5VC4
Crystal structure of HUMAN WEE1 KINASE domain in complex with Bosutinib-isomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Wee1-like protein kinase | polymer | 289 | 32440.9 | 1 | UniProt (P30291) Pfam (PF00069) In PDB | Homo sapiens (Human) | WEE1hu,Wee1A kinase |
| 2 | A | 4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE | non-polymer | 530.4 | 1 | Chemie (XZN) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gly 289 | - | expression tag |
| Ser 290 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32440.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 625.4 | |
| All* | Total formula weight | 33066.3 |
