5VD7

CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue

Summary for 5VD7

• Entry DOI: 10.2210/pdb5vd7/pdb
• Related: 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD8 5VD9 5VDA
• Descriptor: Wee1-like protein kinase, 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: kinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33057.01

Authors

Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-04-01, release date: 2018-04-04, Last modification date: 2023-10-04)

• Primary citation: Zhu, J.-Y.,Schonbrunn, E.; Structural basis of Wee family kinase inhibition by small molecules; to be published,

Experimental method

X-RAY DIFFRACTION (2.08 Å)